目的 对人参临床应用研究相关中、英文文献进行可视化分析，探析人参临床应用研究的现状、挑战与未来研究趋势。方法 检索中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、维普生物医学数据库（VIP）、Web of Science、Pubmed数据库在2005年6月1日—2025年6月1日间的中、英文人参临床应用研究文献，运用CiteSpace等软件对年度发文量、国家、机构、关键词、联合用药等方面进行分析，绘制可视化图谱。结果 共检索到中文文献1 110篇，英文文献341篇。人参临床应用研究在国内外均呈现前上升中平缓后下降的趋势。英文文献发文量最大的国家是韩国。中文文献人参涉及多种联合给药方式。中文文献人参皂苷Rg₃、人参多糖、人参总皂苷的研究较多，英文文献人参皂苷Rb₁、人参皂苷CK、人参提取物的研究较多。中文文献更关注心脏疾病、癌症、失眠等，英文文献更关注神经系统疾病、糖尿病、慢性疲劳等。结论 人参临床研究面临着严峻的挑战，国内外对人参临床价值的侧重点有所不同，国际市场竞争激烈。关注人参临床价值，提高质量控制，推动应用转化，是促进人参产业发展的重要保障。

Objective To conduct a visual analysis of Chinese and English literatures related to the clinical application research of Panax ginseng, and explore the current status, challenges, and future research trends of its clinical use. Methods The China National Knowledge Infrastructure（CNKI）, Wanfang Database, VIP Database, Web of Science, and PubMed were used as data sources for Chinese and English literatures from 1 st June, 2005 to 1 st June, 2025. Software such as CiteSpace was employed to analyze and visualize the literatures in terms of annual publication volume, countries of origin, research institutions, keywords, combined drug administration regimens, and other dimensions. Results A total of 1 110 Chinese literatures and 341 English literatures were retrieved. Both domestically and internationally, the number of clinical trials on P. ginseng showed a trend of rising in the early stage, leveling off in the middle stage, and declining in the later stage over the past two decades. South Korea contributed the largest number of English literatures. In Chinese literatures, P. ginseng has been involved in multiple combined drug administration regimens, particularly in the treatment of chronic diseases; Studies on ginsenoside Rg₃, ginseng polysaccharides, and total ginsenoside saponins were more prominent. In English literatures, studies focused more on ginsenoside Rb₁, ginsenoside CK, and ginseng saponin extracts. Additionally, Chinese literatures concentrated on diseases such as heart diseases, cancer, and insomnia, while English literatures paid more attention to neurological diseases, diabetes, and chronic fatigue syndrome. Conclusion The clinical application research of P. ginseng is facing significant challenges. The research directions regarding the clinical value of P. ginseng differ between China and other countries, and competition in the international market is intense. Focusing on the clinical value of P. ginseng, improving quality control standards, and promoting the transformation of research findings into clinical applications are important guarantees for advancing the development of the P. ginseng industry.

R285;R284

中国工程院院地合作项目:“人参品质与临床价值评价策略研究”(2024-DFZD-28)