前列腺是男性特有的性腺器官，上皮-间质转化（EMT）在前列腺细胞生物学行为中扮演着重要角色，影响多种前列腺疾病发生发展。EMT是一个复杂的细胞过程，表现为上皮细胞失去其极性、细胞间连接和基底膜附着改变，并获得间质细胞的特性。非编码RNA（ncRNA）参与调控前列腺上皮细胞EMT过程，在前列腺疾病中发挥关键作用。近年来，中药在EMT介导的前列腺疾病中作用的研究日益增多，并逐渐成为研究焦点。基于此，围绕ncRNA在前列腺EMT中的调控机制及中药干预作用展开综述，追踪前列腺疾病EMT进程中ncRNA的调控作用及潜在机制的研究前沿，归纳近年常见中药及其成分的干预作用，探讨其作为前列腺疾病诊断和治疗靶点的潜力，为前列腺疾病的治疗提供新思路。

The prostate is a male-specific sex gland organ. Epithelial-mesenchymal transition (EMT) plays a significant role in the biological behavior of prostate cells and influences the occurrence and development of various prostate diseases. EMT is a complex cellular process characterized by the loss of polarity, intercellular connections, and basement membrane attachment of epithelial cells, as well as the acquisition of mesenchymal cell properties. Non-coding RNA (ncRNA) is involved in regulating the EMT process in prostate epithelial cells and plays a key role in prostate diseases. In recent years, research on the role of traditional Chinese medicine in EMT-mediated prostate diseases has been increasing and has gradually become a research focus. Based on this, this article intends to review the regulatory mechanism of ncRNA in prostate EMT and the intervention effect of traditional Chinese medicine, track the research frontiers of the regulatory role and potential mechanisms of ncRNA in the EMT process of prostate diseases, summarize the intervention effects of common traditional Chinese medicines and their components in recent years, and explore their potential as diagnostic and therapeutic targets for prostate diseases, providing new ideas for the treatment of prostate diseases.

R285.5

国家自然科学基金资助项目（82374250）；天津市研究生科研创新项目（2022BKY192）；天津中医药大学研究生科研创新项目（YJSKC-20221018）