消化道肿瘤是全球疾病致死的主要原因之一，其发病率和死亡率不断增加，严重危害人类的健康。由于消化道肿瘤大多发病机制复杂，转移复发率较高，治疗难度大，生存率较低，其防治工作已成为全球重大科学问题。腺苷酸活化蛋白激酶（AMPK）是调节细胞内部能量代谢的重要感受器，而AMPK信号通路与消化道肿瘤细胞生长、增殖、凋亡、侵袭等息息相关，是抗消化道肿瘤治疗的关键通路。中医药以整体观念、辨证论治的总体理念，具有标本兼顾、灵活配伍、高效低毒等显著优势，在抗消化道肿瘤方面疗效突出，广受青睐。中药活性成分如黄酮类、生物碱类、萜类、皂苷类、内酯类以及中药复方如虎七散、固本消积方、固正消癌方、左金丸以及固脾消积饮等可通过调控AMPK及其互作信号通路，诱导细胞自噬和凋亡、调节能量代谢、抑制有氧糖酵解、抑制上皮间质转化、逆转细胞耐药等机制，发挥抗消化道肿瘤作用。对近年来中药治疗消化道肿瘤的研究成果进行归纳和总结，从中药活性成分及中药复方调控AMPK信号通路抑制消化道肿瘤进展的角度进行综述，旨在为抗消化道肿瘤新药开发提供思路和参考。

Digestive tract tumors are one of the main causes of death worldwide. Their morbidity and mortality are increasing, which seriously endangers human health and well-being. Due to the complex pathogenesis of digestive tract tumors, high recurrence rate of metastasis, difficult treatment and low survival rate, its prevention and treatment has become a major scientific problem in the world. Adenosine monophosphate activated protein kinase (AMPK) is an important receptor regulating energy metabolism in cells. AMPK signaling pathway is closely related to the growth, proliferation, apoptosis, invasion and other life activities of digestive tract tumor cells, and is a key pathway for anti-digestive tract tumor therapy. Traditional Chinese medicine, based on the holistic concept and the overall concept of syndrome differentiation and treatment, has significant advantages such as specimen consideration, flexible compatibility, high efficiency and low toxicity, and has outstanding efficacy in anti-digestive tract tumors, and is widely favored. It has been found that the active ingredients of traditional Chinese medicine such as flavonoids, alkaloids, terpenoids, saponins and lactones, as well as the compounds of traditional Chinese medicine such as Huqi Powder, Gubenxiaoji Prescription, Guzheng Xiaoyou Prescription, Zuojin Pill and Gupi Xiaoji Yin can induce autophagy and apoptosis of cells, regulate energy metabolism, inhibit aerobic glycolysis, inhibit epithelial mesenchymal transformation and reverse cell resistance by regulating AMPK and its interaction signaling pathway. To play an anti-digestive tract tumor role. In this paper, the research results on the treatment of digestive tract tumors by traditional Chinese medicine in recent years were summarized and reviewed from the perspective of regulating AMPK signaling pathway and inhibiting digestive tract tumor progression, aiming to provide ideas and references for anti-digestive tract tumors.

R979.1

国家自然科学基金资助项目（81804057）；河南省中医药科学研究专项课题（2022ZY2018）