目的 探索糖尿病治疗药物相互作用研究的热点及趋势。方法 检索中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、维普生物医学数据库（VIP）和Web of Science（WOS）数据库，收集与研究目的相关文献，采用CiteSpace、VOS Viewer、COOC和Excel软件进行数据可视化和文献计量学分析。结果 共纳入82篇中文文献和174篇英文文献；作者分析显示共出现113位核心作者；国内发文机构多为大学及附属医院，平均发文量4篇，国际发文机构集中于跨国制药公司，平均发文量7篇；发文量排名前3的国家分别为美国、印度、中国；排名前3的共被引文献分别关注二甲双胍和恩格列净的药动学以及2型糖尿病的药物管理共识算法；关键词显示降糖药物出现频次由高到低分别为二甲双胍、胰岛素、瑞格列奈；突现词分析显示近5年的中文突现词为转运体、新型冠状病毒肺炎、氯吡格雷、基因多态性、药动学；英文突现词包括elderly、polypharmacy、drug-food interactions、hypertension。结论 二甲双胍与其他药物的相互作用仍是糖尿病治疗药物相互作用的研究热点，基因多态性、老年人群及药物-食物间相互作用或将成为未来研究重点。

Objective To explore the research hotspots and trend of drug-drug interactions in diabetes mellitus, and to provide intuitive data reference and relevant suggestions for subsequent research. Methods CNKI, Wanfang, VIP and Web of Science (WOS) databases were searched to collect papers related to the research purpose. CiteSpace, VOS Viewer, COOC and Excel were used for data visualization and bibliometric analysis. Results A total of 82 Chinese papers and 174 English papers were included. Author analysis showed that there were 113 core authors. Most of the domestic publishing institutions were universities and affiliated hospitals, with an average of four papers, while international publishing institutions were concentrated in multinational pharmaceutical companies, with an average of seven papers. The top three countries with the highest number of articles are the United States, India and China. The top three co-citations focused on the pharmacokinetics of metformin and enaglipzin and the consensus algorithm for drug administration in type 2 diabetes respectively. Metformin, insulin and repaglinide were the frequency of hypoglycemic drugs from high to low in keywords analysis. The analysis of burst words showed that the Chinese burst words in recent 5 years were transporter, novel coronavirus pneumonia, clopidogrel, gene polymorphism and pharmacokinetics. The English burst words included elderly, polypharmacy, drug-food interactions, and hypertension. Conclusion The interaction between metformin and other drugs is still a research hotspot in the treatment of diabetes. Gene polymorphism, elderly population and drug-food interaction may become the focus of future research in the treatment of diabetes.

R969.2

中国药品监督管理研究会研究课题-基于多元证据体探索中成药安全性评价方法的研究（2024-Y-Y-006）；临床研究和成果转化能力提升试点项目-中药制剂研发——治疗胃轻瘫中药复方佛香散（DZMG-ZJXY-23002）。