骨质疏松症（OP）是一种常见的全身性代谢性骨病。依据病因，OP可分为原发性OP和继发性OP。OP主要表现为骨密度（BMD）降低和骨质破坏，容易导致骨折和功能障碍。临床上主要采用抑制骨吸收药物降钙素以及促进骨形成药物甲状旁腺激素等化学药物治疗OP，常用的抗OP中药有黄芪以及红芪-淫羊藿复方等。红芪为补益类中药，具有抗炎、免疫调节、抗氧化、防治糖尿病并发症等广泛的药理作用，历代本草中多将红芪列入黄芪项下，作为黄芪使用，红芪在增强免疫力、清除自由基活性、抗肝纤维化方面要优于黄芪。目前有研究发现红芪中的黄酮类成分和多糖类成分可以通过促进骨形成、抑制骨吸收和增大BMD等作用机制改善OP，但对红芪改善OP的系统性总结比较少。系统阐释红芪抗OP作用及相关的机制，为红芪改善OP作用的深入探讨和有效成分的进一步开发利用提供基础参考。

Osteoporosis (OP) is a common systemic metabolic bone disease. Depending on the cause, osteoporosis can be divided into primary OP and secondary OP. Osteoporosis is mainly manifested by bone density reduction and bone destruction, which can easily lead to fractures and dysfunction. In clinical practice, chemical drugs such as calcitonin, which inhibits bone resorption, parathyroid hormone, which promotes bone formation, and Astragali Radix, Hedysari Radix-Epimedium are used to treat osteoporosis. Hedysari Radix is a tonic Chinese medicine, which has a wide range of pharmacological effects such as anti-inflammatory, immune regulation, antioxidant, prevention and treatment of diabetes complications, etc. In the past dynasties, it was mostly included under Astragali Radix. When used Astragali Radix, Hedysari Radix is better than Astragali Radix in enhancing immunity, scavenging free radical activity and anti-liver fibrosis. Current studies have found that flavonoids and polysaccharides in Hedysari Radix can improve osteoporosis by promoting bone formation, inhibiting bone absorption and increasing bone density. Therefore, this paper systematically explains the anti-osteoporosis effect of the effective ingredients of Hedysari Radix and the related mechanism, so as to provide a basic reference for the in-depth discussion of the effect of Hedysari Radix on improving osteoporosis and the further development and utilization of the effective ingredients.

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天津市制造业高质量发展专项资金—天津天士力之骄药业有限公司技术中心创新能力建设（ZZY20232088）