心血管疾病包括高血压、动脉粥样硬化、心肌梗死、心律失常、心肌病、瓣膜性心脏病、先天性心血和心力衰竭。铁死亡（ferroptosis）属于新的程序性细胞死亡方式，其病理特征是脂质过氧化和铁过载，心血管疾病中铁死亡调控的主要途径包括铁代谢、脂质代谢和氨基酸代谢等。近年来，中药通过铁死亡途径发挥心血管疾病治疗作用方面的研究愈来愈多，总结近5年中药成分及复方制剂通过铁死亡在心肌梗死、心力衰竭、心肌病、高血压等心血管疾病的治疗效果及相关作用通路，进一步挖掘心血管疾病的治疗靶点，以期为心血管疾病的治疗及新药研发提供新思路。

Cardiovascular diseases include hypertension, atherosclerosis, myocardial infarction, arrhythmia, cardiomyopathy, valvular Heart disease, congenital heart disease, and heart failure. Ferroptosis is a new mode of programmed cell death, which is characterized by lipid peroxidation and iron overload. The main regulatory pathways of iron death in cardiovascular diseases include iron metabolism, lipid metabolism and amino acid metabolism. In recent years, there have been more and more studies on the treatment of cardiovascular diseases by iron death of traditional Chinese medicine. This study aims to review the therapeutic effects and related pathways of traditional Chinese medicine components and compound preparations by iron death in cardiovascular diseases such as myocardial infarction, heart failure, cardiomyopathy and hypertension in the past five years, and further explore therapeutic targets for diseases. In order to provide new ideas for the treatment of cardiovascular diseases and the development of new drugs.

天津市制造业高质量发展专项资金—天津天士力之骄药业有限公司技术中心创新能力建设（ZZY20232088）