目的 评估和分析1984年—2023年关于氢吗啡酮研究的论文数量和研究现状、研究热点以及相关基因及疾病研究趋势。方法 采用文献计量学的方法检索1984年—2023年Web of Science核心数据库（WoS）和中国学术期刊全文数据库（CNKI）有关氢吗啡酮的文献，利用多种文献计量学软件和公共数据库平台对国家、机构、作者、期刊、共被引文献、关键词，基因及疾病进行可视化分析。结果 近40年，有关氢吗啡酮的研究发展迅速，国内外数据库中氢吗啡酮相关研究均逐年增加，近10年增长更快。中英文关键词聚类分析显示，目前对氢吗啡酮的研究以慢性疼痛、术后镇痛、疼痛管理、麻醉为主；氢吗啡酮研究相关基因进行聚类分析发现，黏液型阿片样受体（OPRM1）、肾素结合蛋白（RENBP）、白细胞介素6 （IL-6）和CYP450 2D6酶（CYP2D6）热度较高。白蛋白（ALB）、人胰岛素（INS）、PPIG、细胞色素P450 3A4酶（CYP3A4）、IL-6、肿瘤坏死因子（TNF）、前列腺素内过氧化物合酶 2（PTGS2）、阿黑皮素原（POMC）、OPRM1、细胞色素P450 1A2酶（CYP1A2），这些蛋白可能为与氢吗啡酮研究密切相关的核心蛋白。结论 氢吗啡酮相关研究的数量及质量均快速增长，研究热点集中于癌性疼痛、急慢性疼痛管理、不良反应等。这些分析对深入理解氢吗啡酮的药效学和药动学及确定未来研究方向提供一定的借鉴。

Objective To evaluate and analyze the number of research papers on hydromorphone from 1984 to 2023, the research status, research hotspots, and research trends of related genes and diseases. Methods The literature related to hydromorphone studies from 1984 to 2023 in the Web of Science Core database (WoS) and China National Knowledge Infrastructure (CNKI) was retrieved by bibliometrics method. A variety of bibliometrics software and public database platform were used to visually analyze countries, institutions, authors, journals, co-cited literatures, keywords, genes and diseases. Results Over the past 40 years, the research on hydromorphone has developed rapidly. And the research on hydromorphone in domestic and foreign databases has increased year by year, and the growth has been faster in the past decade. The current research on hydromorphone mainly focuses on chronic pain, postoperative analgesia, pain management, and anesthesia. Cluster analysis of genes related to hydromorphone study showed that OPRM1, RENBP, IL-6 and CYP2D6 were highly popular. ALB, INS, PPIG, CYP3A4, IL-6, TNF, PTGS2, POMC, OPRM1, CYP1A2 may be the core proteins closely related to hydromorphone research. Conclusion The quantity and quality of hydromorphone related research are increasing rapidly. Research hotspot focused on cancerous pain, acute or chronic pain management, adverse reactions, etc. These analyses provide some reference for further understanding of the pharmacodynamics and pharmacokinetics of hydromorphone and for determining the future research direction.

R982

武汉市科技局2022年度知识创新专项基础研究项目（2022020801010535）；吴阶平医学基金会临床科研专项资助基金项目（320.6750.2024-11-01）