目的 分析2000—2022年逍遥散研究现状，并预测其发展趋势，为该复方的进一步研究提供借鉴。方法 利用中国学术期刊全文数据库（CNKI）和Web of Science（WoS）核心集数据库，检索逍遥散相关文献，使用CiteSpace软件对发文量趋势、作者、机构、关键词等进行可视化分析。结果 经数据清洗，得到中文文献956篇，英文文献225篇；自2000年以来，逍遥散发文量呈逐年上升趋势；陈家旭（北京中医药大学）、秦雪梅（山西大学）、曾南（成都中医药大学）是该领域发文量前3的作者，其所在单位同样为主要研究机构；中文文献主要集中在抑郁症、乳腺癌及月经不调等方面，英文文献主要聚焦在抑郁症方面；近年来逍遥散研究热点逐渐由乳腺癌、月经不调、黄褐斑等向抗抑郁领域发展，其抗抑郁症机制主要集中在单胺类神经递质、神经内分泌、神经营养因子、能量代谢、肠道菌群、免疫等方面。但是，目前在逍遥散抗抑郁研究方面存在一些复方应用层面的问题，包括药味组成比例不统一、用药剂量范围过大、单味药是否炮制以及提取方法各有不同等，这将造成所制备的提取物存在较大差异，因此所引起的药效及其作用机制可能也有所不同，这些问题制约了其长远发展。结论 逍遥散的研究正处于快速发展阶段，临床应用及实验研究方面已有大量积累，但因抑郁症发病机制复杂，逍遥散抗抑郁机制方面的研究仍需继续深入，如利用同位素示踪代谢组学、肠道微生物组学、单细胞转录组学等对其能量代谢、菌群调节和免疫调控的作用机制进行深入研究，为逍遥散的抗抑郁研究带来突破性创新。

Objective To analyze the research status of Xiaoyao Powder over the past 20 years (from 2000 to 2022) and predicted its development trends to provide insights for further research on this formula. Methods Relevant literature on Xiaoyao Powder was retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WoS) core collection databases. CiteSpace software was used for visual analysis of publication trends, authors, institutions, and keywords. Results After data cleaning, 956 Chinese and 225 English publications were obtained. The number of publications on Xiaoyao Powder has increased annually since 2000. Chen Jiaxu (Beijing University of Chinese Medicine), Qin Xuemei (Shanxi University), and Zeng Nan (Chengdu University of Traditional Chinese Medicine) are the top three authors in terms of publication volume, with their respective institutions being the major research institutions. Chinese literature mainly focuses on depression, breast cancer, and menstrual disorders, and English literature predominantly concentrates on depression. In recent years, the research focus of Xiaoyao Powder has gradually developed from breast cancer, menstrual disturbance, melasma, etc., to the field of anti-depression. Its anti-depression mechanism mainly focuses on monoamine neurotransmitters, neuroendocrine, neurotrophic factors, energy metabolism, intestinal flora, immunity and other aspects. However, at present, there are some problems in the application of Xiaoyao Powder in the study of anti-depression, including the difference in the composition ratio of drug flavor, the large dosage range, and the different processing and extraction methods of single flavor drugs, which will cause great differences in the prepared extracts, so the drug effects and mechanism of action may also be different. Conclusion The research on Xiaoyao Powder is in a stage of rapid development, and a large amount of clinical applications and experimental studies have been accumulated. However, due to the complex pathogenesis of depression, the research on the anti-depression mechanism of Xiaoyao Powder still needs to be further deepened. For example, isotope tracer metabolomics, intestinal microbiome and single cell transcriptomics were used to conduct in-depth studies on the mechanisms of its energy metabolism, flora regulation and immune regulation, which brought breakthrough innovations for the anti-depression research of Xiaoyao Powder.

R285

国家自然科学基金资助项目（82204656）