目的 分析四神丸的研究现状及发展趋势。方法 检索中国学术期刊全文数据库（CNKI）、万方数据知识服务平台、维普生物医学数据库（VIP）从2000年1月1日－2024年3月12日收录的四神丸基础研究和临床研究的中文文献。基于文献计量学方法，借助文献管理NoteExpress V3.0和可视化作图软件CiteSpace6.2.R6对数据进行整理与可视化分析，并绘制知识图谱。结果 四神丸基础研究与临床研究分别纳入文献128、401篇，年发文量总体呈波动上升趋势；基础研究有多个研究团队形成，其中刘端勇团队有较大影响力，临床研究尚未形成较大影响力的团体；基础研究机构形成了以甘肃中医药大学为中心的较大合作网络，临床研究机构尚未形成较大的合作网络；基础研究的热点以溃疡性结肠炎、信号通路、肠道菌群等为主，临床研究以溃疡性结肠炎、临床疗效、名家经验等热点为主。结论 现阶段四神丸的基础和临床研究取得了显著成果，其基础研究正逐步深入，特别是在细胞凋亡、自噬、能量代谢和肠道菌群方面，以期解析其调节机制，促进更广泛的临床应用。

Objective To analyze the current research status and development trends in the field of Sishen Pills studies. Methods Chinese literature on the basic and clinical research of Sishen Pills published between January 1, 2000, and March 12, 2024, was retrieved from CNKI, Wanfang, and VIP databases. Using bibliometric methods, the data were organized and visualized with NoteExpress V3.0 and CiteSpace 6.2.R6, and a knowledge map was created. Results A total of 128 articles on basic research and 401 articles on clinical research were included, showing a fluctuating upward trend in annual publication volume. Several research teams have formed in basic research, with the team led by Liu Duanyong being notably influential. However, no influential groups have emerged in clinical research. A large collaborative network centered around Gansu University of Chinese Medicine has formed in basic research, while clinical research institutions have yet to form significant collaborative networks. Hotspots in basic research mainly include ulcerative colitis, signaling pathways, and gut microbiota, while clinical research focuses on ulcerative colitis, clinical efficacy, and renowned experts' experiences. Conclusion At the current stage, significant achievements have been made in both the basic and clinical research of Sishen Pills. The foundational studies on Sishen Pills are progressively deepening, particularly in the areas of apoptosis, autophagy, energy metabolism, and intestinal microbiota, aiming to elucidate their regulatory mechanisms to foster broader clinical applications.

R96

国家自然科学基金资助项目（82160870）;江西省自然科学基金资助项目（20224BAB206099）;江西省中医药中青年骨干人才项目培养计划（赣中医药科教字〔2022〕7号）;江西中医药大学科技创新团队（CXTD22009）