目的 基于CiteSpace 6.1.R6对苦参进行文献计量学及可视化分析，了解其研究现状及趋势，为将来的基础研究和临床研究提供参考。方法 检索维普生物医学数据库（VIP）、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（SinoMed）和Web of Science（WOS）数据库，限制文献发表时间为2014—2023年。利用NoteExpress软件对文献进行筛选并应用CiteSpace 6.1.R6版软件对文献作者、机构、关键词进行可视化分析，提取可靠信息。结果 共检索到中文文献1 887篇和英文文献421篇。可视化分析结果显示近10年中文文献的发文量整体呈下降趋势，英文文献发文量趋于稳定，略有上升，中文文献量远多于英文文献量。作者合作网络分析结果显示作者之间存在交流合作并且形成了研究团队，团队内部存在合作，团队之间缺乏交流。机构之间合作较少，存在跨省交流与跨国合作。关键词共现分析表明苦参的成分苦参碱和氧化苦参碱有较高的研究价值，苦参具有抗肿瘤、抗菌、抗炎等作用，其中抗炎作用是当前研究的热点。结论 目前苦参的研究主要集中于对其抗肿瘤和抗炎作用，而发挥作用的主要成分为苦参碱；未来对苦参的药用价值和药理作用机制应进行更加全面、深入且多角度的探索，以期构建一个系统化的研究体系。

Objective To conduct bibliometric and visualization analysis of the traditional Chinese medicine (TCM) Sophora flavescens using CiteSpace 6.1. R6, understand its current research status and trends, and provide references for future basic and clinical research. Methods Literature was retrieved from the VIP Chinese Medical Journal Database (VIP), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Service System (Sinomed), and Web of Science (WOS) databases, with publication dates limited from 2014 to 2023. NoteExpress software was used for literature screening, and CiteSpace 6.1. R6 software was employed for visual analysis of authors, institutions, and keywords to extract reliable information. Results A total of 1 887 Chinese literatures and 421 English literatures were retrieved. Visualization analysis indicated that over the past decade, the number of publications in Chinese has been declining, while the number of published articles in English tended to be stable and slightly increased. The number of publications in Chinese significantly exceeded that in English. The author cooperation network analysis demonstrated that communication and collaboration among authors, forming research teams with internal collaboration but lacking inter-team communication. There was limited cooperation between institutions, encompassing interprovincial exchanges and transnational collaboration. Keywords co-occurrence analysis showed that the components of S. flavescens namely matrine and oxymatrine, had high research value. S. flavescens exhibited anti-tumor, anti-bacterial and anti-inflammatory properties, with antiinflammatory effects being a current research hotspot. Conclusion Currently, the research on S. flavescens focuses on its anti-tumor and anti-inflammatory effects, and the main component of S. flavescens is matrine and oxymatrine, in the future, the medicinal value and pharmacological mechanism of S. flavescens should be explored in a more comprehensive, in-depth and multi-faceted way, with the aim of constructing a systematic research system.

R285.5

国家自然科学基金面上项目(82301725);山西省重点研发计划项目(2106ZD0503);山西省基础研究计划项目(202303021222386);中国博士后科学基金第73批面上资助项目(2023M732155);山西省基础研究计划面上项目(202203021212028);山西省高等学校科技创新项目(2022L132);山西省卫生健康委中医药科研项目(2023ZYYC2034);山西医科大学校级博士启动基金项目(XD2102);山西医科大学第一医院青年项目(YQ2203);经方扶阳山西省重点实验室开放课题(CPSY202301);山西省高等学校科技创新项目资助项目(2023W185);山西省哲学社会科学规划课题(2023YJ141)。