目的 探讨紫杉醇涂层球囊对老年冠心病患者治疗效果，及对靶血管直径、心血管不良事件（MACE）的影响。方法 选择2020年6月—2022年6月南京医科大学附属无锡人民医院收治的老年冠心病患者82例，随机分为观察组41例、对照组41例。对照组采用药物洗脱支架治疗，观察组采用紫杉醇药物涂层球囊（DCB）治疗。比较两组总有效率、心功能指标、靶病变管腔直径及狭窄率、MACE发生率。结果 术后，观察组总有效率（97.56%）较对照组（82.93%）显著升高（P＜0.05）；观察组左室射血分数（LVEF）、每搏输出量（SV）较本组治疗前显著上升（P＜0.05），且显著高于对照组（P＜0.05）；观察组靶病变管腔狭窄率较本组治疗前显著降低（P＜0.05），且显著低于对照组（P＜0.05），管腔直径较本组治疗前显著增加（P＜0.05），且显著大于对照组（P＜0.05）；观察组MACE发生率显著低于对照组（P＜0.05）。结论 对老年冠心病患者采用紫杉醇涂层球囊治疗，可有效缓解患者临床症状，改善心功能，减少MACE发生率，在临床上值得推广。

Objective: To investigate the therapeutic effect of paclitaxel coated balloon on elderly patients with coronary heart disease, and its impact on target vessel diameter and cardiovascular adverse events (MACE). Method A total of 82 elderly patients with coronary heart disease admitted to Wuxi People's Hospital Affiliated to Nanjing Medical University from June 2020 to June 2022 were randomly divided into an observation group of 41 cases and a control group of 41 cases. The control group was treated with drug-eluting stents, while the observation group was treated with paclitaxel coated balloon (DCB). Compare the total effective rate, cardiac function indicators, target lesion lumen diameter and stenosis rate, and MACE incidence between two groups. Results After surgery, the total effective rate of the observation group (97.56%) was significantly higher than that of the control group (82.93%) (P < 0.05). The left ventricular ejection fraction (LVEF) and stroke volume (SV) in the observation group were significantly increased compared to before treatment（P < 0.05）, and were significantly higher than those in the control group（P < 0.05）. The stenosis rate of the target lesion lumen in the observation group was significantly decreased compared to before treatment（P < 0.05）, and significantly lower than that in the control group (P < 0.05). The lumen diameter was significantly increased compared to before treatment（P < 0.05）, and significantly larger than that in the control group (P < 0.05). The incidence of MACE in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion The use of paclitaxel coated balloon therapy for elderly patients with coronary heart disease can effectively alleviate clinical symptoms, improve heart function, and reduce the incidence of MACE. It is worth promoting in clinical practice.

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