目的 总结 2000 年以来巴戟天的研究进展，预测其未来研究热点和趋势。方法 使用 CiteSpace文献计量学方法，分别从中国学术期刊全文数据库（CNKI）、万方数据知识服务平台、中国生物医学文献数据库（SinoMed）、维普生物医学数据库（VIP）、PubMed和Web of Science数据库中，收集巴戟天相关的中英文文献，整理去重后采用CiteSpace等软件分别对中英文文献的发文量、作者、发文机构、文献被引频次、关键词等进行统计和分析。结果 共纳入文献2 076篇，其中中文文献1 636篇，英文文献440篇。可视化分析结果显示巴戟天相关的年发文量总体呈现增长的态势。中、英文收录文献最多的期刊分别是《中药材》和Molecules。被引频次前10的中英文文献主要研究方向为巴戟天抗抑郁、抗骨质疏松、抗炎等药理作用。作者合作网络分析显示作者之间的合作不够密切，且该领域主要由国内学者进行研究。对中文文献的关键词分析发现：频数最高的关键词为“药理作用”；中心性最大的关键词是“成分分析”；产生了 10个聚类，主要集中在药理作用、成分分析、临床应用等方面；突现词有15个，其中“抗抑郁”的突现性最高。对英文文献的关键词分析发现：“抗抑郁”是频数最大、中心性最高的关键词；生成了 8 个聚类，主要集中在抗抑郁、抗炎作用及其机制研究上；突现词有 17个，其中“抗炎”突现性最高。结论 当前巴戟天的研究涉及化学成分、药理作用、药物配伍和质量控制等方面，抗抑郁和抗骨质疏松等药理作用可能成为未来的研究重点。部分药理作用研究仍处于实验阶段，相应的临床制剂开发需要进一步推进。

Objective To summarize the research progress on Morinda officinalis since 2000 and to predict future research hotspots and trends. Methods Using the bibliometric method of CiteSpace, the research progress on M. officinalis was analyzed to identify research hotspots and trends. Relevant Chinese and English literature on M. officinalis was extracted from the China National Knowledge Infrastructure (CNKI), VIP, Wanfang, SinoMed, PubMed, and Web of Science databases. After deduplication, CiteSpace and other software were used to statistically analyze the publication volume, authors, institutions, citation frequency, and keywords of the literature in both languages. A total of 2 076 articles were included, comprising 1 636 Chinese articles and 440 English articles. Results A total of 2 076 articles were included in the analysis, among which 1 636 were in Chinese and 440 in English. The visualization analysis results indicate that the annual publication volume related to M. officinalis has shown an overall increasing trend. The journals with the most articles on M. officinalis in Chinese and English were "Chinese Herbal Medicines" and "Molecules, " respectively. The top 10 most cited Chinese and English articles primarily focused on the pharmacological effects of M. officinalis, such as its antidepressant, anti-osteoporotic, and anti-inflammatory properties. The author collaboration network analysis revealed that collaboration among authors was not very close, and the field was mainly studied by domestic scholars. Keyword analysis of Chinese literature showed that the most frequent keyword was "pharmacological effects", and the keyword with the highest centrality was "component analysis." Ten clusters were identified, mainly focusing on pharmacological effects, component analysis, and clinical applications. There were 15 burst terms, with "antidepressant" having the highest burst strength. In the analysis of English literature, "antidepressant" was the keyword with the highest frequency and centrality. Eight clusters were identified, mainly focusing on antidepressant, anti-inflammatory effects, and their mechanisms. There were 17 burst terms, with "anti-inflammatory" having the highest burst strength. Conclusion Current research on M. officinalis involves chemical components, pharmacological effects, drug compatibility, and quality control. Pharmacological effects such as antidepressant and anti-osteoporotic activities may become key focuses of future research. Some pharmacological studies are still in the experimental stage, and the development of corresponding clinical formulations needs further advancement.

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云浮市2022年中医药（南药）产业创新团队项目（云科函［2022］71号）