目的 通过Meta分析的方法评价稳心颗粒对房颤患者心脏结构重构及炎症因子的影响。方法 检索PubMed、Embase、Cochrane Library、Web of Science、中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、中国生物医学文献数据库（CBM）、维普生物医学数据库（VIP）中稳心颗粒治疗房颤的临床随机对照试验（RCTs）；使用Excel录入文献基本信息；使用RevMan 5.4进行质量评价、异质性检验及森林图绘制；使用StataMP 17.0进行漏斗图绘制及Egger检验。结果 共纳入39项RCTs，包含4 211例研究对象。Meta分析结果显示：稳心颗粒可提高房颤患者左室射血分数（LVEF，MD＝6.01，95%置信区间（CI）［5.03，6.99］，P＜0.000 01），降低房颤患者左室舒张末期内径（LVEDd，MD＝-6.35，95% CI ［-7.66，-5.04］，P＜0.000 01）、左室收缩末期内径（LVESd，MD＝-4.35，95% CI［-4.80，-3.90］，P＜0.000 01）、左房内径（LAd，MD＝-3.63，95% CI ［-5.43，-1.83］，P＜0.000 1）、超敏C反应蛋白（hs-CRP，MD＝-2.28，95% CI ［-3.07，-1.48］，P＜0.000 01）、C反应蛋白（CRP，MD＝-5.71，95% CI ［-6.62，-4.79］，P＜0.000 01）、白细胞介素-6（IL-6，MD＝-10.37，95% CI ［-17.00，-3.74 ］，P ＝ 0.002 ）、基质金属蛋白酶-9（MMP-9，MD＝-23.27，95% CI ［-26.42，-20.11］，P＜0.000 01）、基质金属蛋白酶-2（MMP-2，MD＝-55.85，95% CI［-90.44，-21.27］，P＝0.002），其差异具有统计学意义。试验组不良反应发生率低于对照组（RR＝0.74，95% CI ［0.59，0.93］，P＝0.009），其差异具有统计学意义。结论 稳心颗粒可改善房颤患者结构重构指标、降低炎症因子，且安全性较好。

Objective To evaluate the effects of Wenxin Granule on structural remodeling and inflammatory markers in patients with atrial fibrillation (AF) by Meta-analysis. Methods PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, SinoMed, VIP and China Biology Medicine disc (CBM) were searched for randomized controlled trials (RCTs) of Wenxin Granule in treatment of AF. Excel was used to input the basic information of the article. RevMan 5.4 was used for quality assessment, heterogeneity test and forest map drawing. StataMP 17.0 was used for funnel plot and Egger test. Results A total of 39 RCTs involving 4 211 participants were included. Results of Meta-analysis showed that:Wenxin Granule could improve left ventricular ejection fraction (LVEF, MD = 6.01, 95%CI [5.03, 6.99], P < 0.000 01), reduce left ventricular end-diastolic diameter (LVEDd, MD = -6.35, 95%CI [ -7.66, -5.04], P < 0.000 01), left ventricular end-systolic diameter (LVESd, MD = -4.35, 95%CI [-4.80, -3.90, P < 0.000 01), left atrial diameter (LAd, MD = -3.63, 95%CI [-5.43, -1.83], P < 0.000 1), hypersensitive C-reactive protein (hs-CRP, MD = -2.28, 95%CI [-3.07, -1.48], P < 0.000 01), C-reactive protein (CRP, MD = -5.71, 95%CI [-6.62, -4.79], P < 0.000 01), interleukin-6 (IL-6, MD = -10.37, 95%CI [-17.00, -3.74], P= 0.002), matrix metalloprotein-9 (MMP-9, MD = -23.27, P < 0.000 01), 95%CI [-26.42, -20.11], P < 0.000 01), matrix metalloprotein-2 (MMP-2, MD = -55.85, 95%CI [ -90.44, -21.27], P= 0.002) in AF patients, the difference was statistically significant. The incidence of adverse reactions in the experimental group was lower than that in the control group (RR = 0.74, 95%CI [0.59, 0.93], P= 0.009), the difference was statistically significant. Conclusion Wenxin Granule can alleviate structural remodeling and reduce inflammatory markers in patients with atrial fibrillation with good safety.

R972

中华中医药学会青年求实项目（2023-QNQS-01）;第六批北京市级中医药专家学术经验继承工作项目