他汀类药物调脂作用显著,是一类较全面的调脂药,能强效降低血清总胆固醇(TC)和低密度脂蛋白(LDL),在心血管疾病预防和治疗中应用广泛。近年来,随着他汀类药物的广泛应用,对其不良反应的研究也日趋深入。肝毒性是此类药物产生的重要不良反应之一,他汀类药物在使用过程中偶有药物性肝损伤(DILI)发生,对他汀类药物致DILI影响因素、相关机制及防治策略的研究进展进行总结,旨在为他汀类药物临床合理使用及DILI的预防提供依据。

Statins are a kind of comprehensive lipid-regulating drugs, which can effectively reduce serum total cholesterol (TC) and low density lipoprotein (LDL). Statins are widely used in the prevention and treatment of cardiovascular disease. In recent years, with the wide application of statins, the research on their adverse reactions is becoming increasingly in-depth. Hepatotoxicity is one of the important adverse reactions caused by such drugs. Drug-induced liver injury (DILI) occasionally occurs during the use of statins. This paper summarizes the research progress on the influencing factors, related mechanisms, and prevention and treatment strategies of DILI caused by statins, aiming to provide a basis for rational clinical use of statins and prevention of DILI.

R965.3