目的 探讨小儿豉翘清热颗粒联合头孢噻肟钠治疗儿童细菌性肺炎疗效及对炎症因子的影响。方法 选取2020年1月—2023年1月聊城市第二人民医院收治的细菌性肺炎患儿108例，根据随机数表法将其分为试验组与对照组，各54例。对照组给予注射用头孢噻肟钠治疗，试验组在对照组基础上联合小儿豉翘清热颗粒进行治疗。治疗7 d后，评估两组患儿临床疗效、中医证候积分、不良反应，对比两组患儿治疗前后免疫指标及炎症因子水平变化。结果 治疗7 d后，试验组总有效率显著高于对照组（P＜0.05）；两组患儿治疗前中医证候积分、免疫指标、炎症因子水平比较差异无统计学意义（P＞0.05）；治疗后两组各中医证候积分、白细胞介素（IL）-6和C反应蛋白（CRP）水平较本组治疗前显著降低（P＜0.05），免疫球蛋白（Ig）A、IgG、IgM水平较本组治疗前显著升高（P＜0.05），且试验组治疗后各中医证候积分、IL-6和CRP水平显著低于对照组（P＜0.05），IgA、IgG、IgM水平显著高于对照组（P＜0.05）；两组患儿不良反应发生率无显著差异（P＞0.05）。结论 小儿豉翘清热颗粒联合头孢噻肟钠对儿童细菌性肺炎具有较好的疗效，能够显著改善患儿中医证候积分、免疫功能和炎症反应。

Objective To explore the curative effect of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium and its influences on inflammatory factors in children with bacterial pneumonia. Methods A total of 108 children with bacterial pneumonia admitted to Liaocheng Second People's Hospital were enrolled between January 2020 and January 2023. According to random grouping method, they were divided into experimental group and control group, 54 cases in each group. Patients in the control group were treated with cefotaxime sodium, while patients in experimental group were additionally treated with Xiao'er Chiqiao Qingre Granules. After seven days of treatment, clinical curative effect, scores of TCM syndromes and adverse reactions in the two groups were evaluated. The changes in levels of immune indexes and inflammatory factors before and after treatment were compared between the two groups. Results After 7 d of treatment, clinical curative effect of experimental group was significantly better than that of control group (P < 0.05). Before treatment, there was no significant difference in scores of TCM syndromes, immune indexes and inflammatory factors between the two groups (P > 0.05). After treatment, scores of TCM syndromes, levels of interleukin (IL)-6 and C-reactive protein (CRP) were significantly decreased (P < 0.05), while levels of immunoglobulin (Ig)A, IgG and IgM were significantly increased in both groups (P < 0.05). After treatment, scores of TCM syndromes, levels of IL-6 and CRP in experimental group were significantly lower than those in control group (P < 0.05), while levels of IgA, IgG and IgM were significantly higher than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Curative effect of Xiao'er Chiqiao Qingre Granule combined with cefotaxime sodium is good in children with bacterial pneumonia, which can significantly improve TCM syndromes, immune function and inflammatory response.

R974