鲍曼不动杆菌感染因广泛的抗菌药耐药性和高死亡率而备受关注,常规抗菌药治疗策略的疗效欠佳。鲍曼不动杆菌和机体免疫反应的相互作用影响感染的严重程度以及临床转归,通过免疫调节改善机体免疫反应是有效的治疗方案。免疫调节剂具有单独治疗或作为免疫佐剂联合抗菌药治疗鲍曼不动杆菌感染的潜力,成为有希望改善感染结局的策略,由此开发的新疗法引起了广泛关注。对不同来源的(生物制剂、免疫系统产物、化学合成制剂、中药或植物药成分)免疫调节剂抗鲍曼不动杆菌感染的研究进展进行阐述,以期对免疫治疗提供帮助。

Acinetobacter baumannii infections are of great concern because of their widespread antimicrobial resistance and high mortality. Conventional antimicrobial drug treatment strategies are not sufficiently effective. The interaction between A. baumannii and the host immune response influences the severity of infection as well as clinical regression. Improving the host immune response through immunomodulation is an effective therapeutic option. Immunomodulators have the potential to treat A. baumannii infections either alone or as immune adjuvants in combination with antimicrobials. It has emerged as a promising strategy to improve infection outcomes. New therapies based on immunomodulators has attracted much attention. In this article, the research progress of different types of drugs against A. baumannii infection(such as biological agents, immune system products, chemically synthesized preparations, traditional Chinese medicine or plant medicine ingredients) were systematically described, hoping to provide help for immunotherapy of A. baumannii infection.

R979.5，R978.1

国家重点研发计划项目(2020YFC2006000)