针对现阶段的网络毒理学研究，系统梳理了网络毒理学在中药安全性研究中的方法特点，实践应用及发展现状，总结了网络毒理学的研究方法与依托工具，对网络毒理学在预测中药不良结局、毒性机制分析、有害成分预判、多学科交叉运用、组学技术联用等方面进行分析归纳。重点关注当前网络毒理学存在的不足与短板，并提出初步的解决策略与完善方案以供同仁参考、批评和借鉴，以期为促进网络毒理学进一步发展及中药安全性评价的构建提供参考。

In view of the current stage of network toxicology research, the characteristics, practical application and development status of network toxicology in the safety research of traditional Chinese medicine were systematically reviewed. The research methods and supporting tools of network toxicology were summarized. The network toxicology was used to predict the adverse outcomes of traditional Chinese medicine, toxicity mechanism analysis, harmful component prediction, multidisciplinary crossapplication, and omics technology. Focus on the shortcomings of current network toxicology and put forward preliminary solutions and improvement plans for colleagues to refer, criticize and learn. In order to provide reference for promoting the further development of network toxicology and the construction of safety evaluation of traditional Chinese medicine.

R285.5

国家自然科学基金资助项目（82204938）