目的 通过对国家中药复方专利治疗溃疡性结肠炎的系统分析，总结归纳其配伍规律及用药发展趋势。方法 检索国家知识产权局中国专利公布网站中治疗溃疡性结肠炎的中药复方专利数据。采用SPSS Statistic 26.0和SPSS Modeler 15.0对高频中药（频次≥20）进行性味归经、功效分析，以及系统聚类、Apriori关联规则与网络分析。以Cytoscape3.7.2构建少见中药高度互联的子网络，挖掘新的药物组合。结果 纳入从建库至2023年8月31日治疗溃疡性结肠炎的中药复方专利共147项，涉及中药500味，高频中药20味，有甘草（60次，40.82%）、黄连（56次，38.10%）、黄芪（46次，31.29%）等，药味以苦味最常见，药性以寒、温为主，多归脾经。以清热药和补益药居多。聚类分析得到4组中药组合（新处方），主要有“黄连、木香、白芍、当归、甘草、陈皮、黄芩、柴胡、茯苓、薏苡仁”等。常用药对有木香-黄连（支持度21.77%，置信度71.88%）等，常用角药组合有白芍-黄连-甘草（支持度14.97%，置信度72.73%）等。挖掘的潜在处方有“假茼蒿-建兰根-橘饼-橘红珠-红娘子-还阳参”等。结论 国家中药复方专利治疗溃疡性结肠炎常用清热解毒药和益气健脾药等，符合溃疡性结肠炎的临床治疗原则。难治性或重度溃疡性结肠炎可考虑攻补兼施之法，适当加入活血化瘀的虫类药。

Objective To summarize and summarize the rules of compounding and the development trend of medication through systematic analysis of national Chinese medicine compounding patents for the treatment of ulcerative colitis. Methods The data of Chinese herbal compound patents for the treatment of ulcerative colitis were retrieved from the Chinese patent publication website of the State Intellectual Property Office. SPSS Statistic 26.0 and SPSS Modeler 15.0 were used to analyze high-frequency traditional Chinese medicines (frequency ≥ 20) for sexual flavor, attribution and efficacy, as well as systematic clustering, Apriori association rules and network analysis. Cytoscape 3.7.2 was used to construct the core complex network of traditional Chinese medicine. Constructing a highly interconnected subnetwork of rare Chinese medicinal herbs using Cytoscape 3.7.2 to unveil novel drug combinations. Results A total of 147 herbal compound patents for the treatment of ulcerative colitis were included from the establishment of the database to August 31, 2023, involving 500 herbal medicines and 20 high-frequency herbal medicines, including Glycyrrhizae Radix et Rhizoma (60 times, 40.82%), Coptidis Rhizoma (56 times, 38.10%) and Astragali Radix (46 times, 31.29%), with bitter taste being the most common and cold and warm properties, mostly attributed to the spleen meridian. Heatclearing drugs and tonic drugs were mostly used. Cluster analysis yielded four groups of herbal combinations (new prescriptions), mainly "Coptidis Rhizoma, Aucklandiae Radix, Paeoniae Radix Alba, Angelicae Sinensis Radix, Glycyrrhizae Radix et Rhizoma, Citri Reticulatae Pericarpium, Scutellariae Radix, Bupleuri Radix, Poria and Coicis Semen". Commonly used pairs include Aucklandiae Radix-Coptidis Rhizoma (support 21.77%, confidence 71.88%), etc. Commonly used corner drug combinations include Paeoniae Radix Alba-Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma (support 14.97%, confidence 72.73%), etc. The potential prescriptions were "Eclipta prostrata-Dendrobium nobile-Citrus aurantium-Citrus reticulata-Epimedium brevicornum", etc. Conclusion The treatment of ulcerative colitis with national herbal compound patent is commonly used to clear heat and detoxify the toxins and benefit the qi and spleen, which is in line with the clinical treatment principle of ulcerative colitis. Refractory or severe ulcerative colitis can be considered as a combination of attacking and tonifying method, with appropriate addition of worm-like drugs that activate blood circulation and remove blood stasis.

R285.5

云南省中医药应用基础研究联合专项-面上项目（202101AZ070001-268）；昆明市卫生健康委员会卫生科研课题（2022-04-01-009）；昆明市卫生科技人才培养项目暨“十百千”工程［2022-SW（后备）-60］