四君子汤是中医经典名方，具有益气健脾的功效，主治脾胃虚弱证，具有调节胃肠功能、增强机体免疫功能等作用。同时，四君子汤也具有防治肿瘤的作用，常用于癌症的辅助治疗。四君子汤对结直肠癌的抗癌作用主要体现在缓解肠道炎症、防治癌前病变、抑制癌症转移、调节机体免疫以及改善肿瘤恶病质等方面，主要综述四君子汤防治结直肠癌药理作用机制的研究进展，以期为四君子汤的应用开发以及抗肿瘤药物的研发提供参考。

Sijunzi Decoction is a classic prescription of traditional Chinese medicine, which has the effect of benefiting qi and strengthening the spleen. It is mainly used for the weakness of spleen and stomach, regulating gastrointestinal function and enhancing the body's immunity. At the same time, Sijunzi Decoction also has the effect of preventing and treating tumors, and is often used in the adjuvant treatment of cancer. The anticancer effect of Sijunzi Decoction on colorectal cancer is mainly reflected in the alleviation of intestinal inflammation, prevention and treatment of precancerous lesions, inhibition of cancer metastasis, regulation of body immunity and improvement of cancer cachexia. This article reviews the recent research progress and status of the pharmacological mechanism of Sijunzi Decoction in the prevention and treatment of colorectal cancer, in order to provide reference for the application and development of Sijunzi Decoction and the research and development of anti-tumor drugs.

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国家自然科学基金资助项目（82205024）；江苏省省级重点研发计划（社会发展）（BE2021611）