人参不仅是我国传统珍贵的中药材，更是食疗保健佳品，具有多方面抗疲劳作用。人参抗疲劳的主要活性成分包括人参多糖、寡肽和皂苷，可能通过调节糖类代谢、激活磷脂酰肌醇-3-羟激酶（PI3K）/蛋白激酶B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）等信号通路、提高骨骼肌线粒体供能效力和加快自由基清除从而产生抗疲劳作用。综述人参多糖、蛋白质、人参皂苷类有效成分抗疲劳药理作用机制，旨在为人参用于各类抗疲劳功能产品的开发应用提供依据。

Ginseng is not only a precious traditional Chinese medicinal herb in China, but also a great food therapy and health product, with various anti fatigue effects. The main active ingredients of ginseng in anti fatigue include ginseng polysaccharides, oligopeptides, and saponins, which may regulate carbohydrate metabolism, activate phosphatidylinositol 3-hydroxykinase (PI3K)/ protein kinase B (Akt)/ mammalian target of rapamycin (mTOR) and other signaling pathways enhance the energy supply efficiency of skeletal muscle mitochondria and accelerate the clearance of free radicals, thereby producing an anti fatigue effect. Summarize the anti fatigue pharmacological mechanisms of ginseng polysaccharides, proteins, and ginsenosides, aiming to provide a basis for the development and application of ginseng in various anti fatigue functional products.

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