[关键词]
[摘要]
柴胡来源于伞形科植物柴胡Bupleurum chinense或狭叶柴胡B.scorzonerifolium的干燥根，其化学成分主要包括柴胡皂苷类、黄酮类、多糖类以及挥发油类等，主要有保肝、调血脂、抗炎等功效。在中医临床中，柴胡常作为君药，应用于治疗各种肝脏疾病的中医组方中。经典名方半夏泻心汤、泽泻汤、温胆汤、小柴胡汤、逍遥散等已用于治疗代谢相关脂肪性肝病（NAFLD）。对柴胡有效成分及经典名方改善NAFLD的临床应用、药理作用及其机制进行综述，以期为深入研究提供理论支撑。
[Key word]
[Abstract]
Radix Bupleuri is the dried root of the umbelliferae plant Bupleurum chinense DC. or B. scorzonerifolium Willd., and its chemical composition mainly includes Radix Bupleuri saponins, flavonoids, polysaccharides, and volatile oils, etc. It is mainly used to protect the liver, lower blood lipids, and anti-inflammatory effects. In traditional Chinese medicine, it is often used as a monarchical drug in Chinese medicine formulas for the treatment of various liver diseases. Classical prescriptions such as Banxia Xiexin Decoction, Zexie Decoction, Wendan Decoction, Xiao Chaihu Decoction, and Xiaoyao San have been used in the treatment of metabolic-dysfunction-associated fatty liver disease (MAFLD). Therefore, the clinical application, pharmacology, and the mechanism of action of the active ingredients of Radix Bupleuri and classical prescriptions for the improvement of MAFLD, which have been mentioned in recent years' related researches, are reviewed, in order to provide scientific and effective theoretical support.
[中图分类号]
R285.5
[基金项目]
国家自然科学基金资助项目（82174099）；山西省基础应用项目面上项目（20210302123432）；名优晋药再开发山西省重点实验室资助项目（202104010910001）；地产中药功效物质研究与利用山西省重点实验室资助项目（201605D111004）
