目的 通过可视化图谱客观、定量分析参附注射液的研究现状和热点方向，为今后深入研究和临床应用提供指导。方法 分别检索中国学术期刊全文数据库（CNKI）、维普中文期刊服务平台（VIP）、万方数据库（Wanfang Data）和Web ofScience核心合集从建库至2023年5月6日收录的参附注射液研究文献，采用人工阅读的方法完成文献数据除重和筛选，使用CiteSpace软件对研究国家、机构和作者合作情况系统分析，绘成关键词共现图、聚类图和突现性分析图。结果 经删选后纳入中文文献3 456篇、英文文献159篇，年发文量均呈波动型。中国为频数最大且中心性最高的国家。对中文文献分析发现：武汉大学人民医院是频数最高的机构；李春盛是发文量最多的作者；频数最高的关键词为“心力衰竭”；中心性最大的关键词是“临床疗效”；产生了10个聚类，大致分为5个方面；突现词有15个，其中“脓毒症”的突现性最高。对英文文献分析发现：Capital Med Univ（首都医科大学）是频数最大、中心性最高的机构；Li Chunsheng（李春盛）是发文量最多的作者；Shenfu Injection（参附注射液）是频数最大、中心性最高的关键词；生成了8个聚类；突现词有17个，其中cardiac arrest（心脏骤停）突现性最高。结论 参附注射液主要适应证为心力衰竭、脓毒症、心脏骤停和重症肺炎等，主要药理作用为抗炎、抗凋亡、改善氧化应激和免疫功能等，主要研究方法为临床随机对照试验和大小鼠动物实验等。

Objective To objectively and quantitatively analyze the research status and hot spots of Shenfu Injection by visual atlas, and to provide guidance for further research and clinical application in the future. Methods The literature on Shenfu Injection included in the Chinese and English databases from CNKI, VIP, Wanfang Data and Web of Science core collection from its establishment to May 6, 2023 were searched respectively. Manual reading was used to complete the reclassification and screening of literature data. CiteSpace software was used to systematically analyze the cooperation between research countries, institutions and authors, and draw keywords co-occurrence map, cluster map and emergence analysis map. Results After deletion, 3 456 Chinese and 159 English literatures were included, and the annual number of publications fluctuated. China is the country with the largest frequency and highest centrality. The analysis of Chinese literature showed that the People's Hospital of Wuhan University was the most frequent institution. Li Chunsheng was the author with the most publications. The keyword with the highest frequency was "heart failure". The key word with the greatest centrality was "clinical effect". Ten clusters were generated, which could be roughly divided into five aspects. There were 15 emergent words, among which "sepsis" was the most emergent. The analysis of English literature showed that Capital Med Univ was the institution with the highest frequency and the highest centrality. Li Chunsheng was the author who published the most articles. Shenfu Injection was the key word with the highest frequency and centrality. Eight clusters were generated. There were 17 sudden words, and cardiac arrest had the highest sudden expression. Conclusion The main adaptive diseases of Shenfu Injection were heart failure, sepsis, cardiac arrest and severe pneumonia, etc. The main pharmacological effects of Shenfu Injection were anti-inflammatory, anti-apoptosis, improvement of oxidative stress and immune function, etc. The main research methods were randomized controlled clinical trials and animal experiments in rats and mice.

R972

国家自然科学基金资助项目（82274412）；广东省重点领域研发项目（2020B1111100001）；湖南省自然科学基金资助项目（2020JJ4062，2020JJ5408）。