动物实验证实厚朴及其有效成分（厚朴酚、和厚朴酚等）具有防治阿尔茨海默病和帕金森病的药理作用。它们最主要的作用机制是抗氧化和抗炎作用：通过直接清除自由基和提高机体的核因子红系2-相关因子-2（Nrf2）抗氧化信号通路和抗氧化酶活性间接清除自由基的方式抑制活性氧生成；通过激活去乙酰化酶（SIRT），阻滞磷脂酰肌醇-3激酶（PI3K）/蛋白激酶-B（Akt），细胞外信号调节蛋白激酶（ERK）/丝裂原活化蛋白激酶（MAPK）和Toll样受体-2（TLR2）/MAPK/核因子-κB（NF-κB）信号通路和促进线粒体自噬，抑制炎性细胞因子表达，保护脑神经（包括海马、黑质和纹状体等），表现出防治阿尔茨海默病和帕金森病的作用。

In animal experiments Magnoliae Officinalis Cortex and its active components (magnolol, honokiol) have the pharmacologic effects in prevention and treatment for Alzheimer`s disease and Parkinson`s disease. Their basic mechanisms are antioxidation and anti-inflammation: by scavenging direct free radial and eliminating indirect free radial through up-regulating Nrf2 anti-oxidative signaling pathway and activity of antioxidases to decrease produce of ROS, and by activation of SIRT, blocking these signaling pathways of PI3K/Akt, ERK/MAPK and TLR2/MAPK/NF-κB, and promoting mitophagy to inhibit the expression of inflammatory cytokines, and to produce neuroprotective effect in brain (including hippocampus, nigra and striatum), so show the effect to prevent and treat for Alzheimer's disease and Parkinson's disease.

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