基于代谢组学方法的中药药效及物质基础的研究进展

doi:10.7501/j.issn.1674-6376.2023.09.025

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2025年6月12日 22:14 星期四

首页 > 过刊浏览>2023年第46卷第9期 >2023,46(9):2024-2029. DOI:10.7501/j.issn.1674-6376.2023.09.025

基于代谢组学方法的中药药效及物质基础的研究进展

王志博
王志博
黑龙江中医药大学研究生院, 黑龙江哈尔滨 150040
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蔡莹
蔡莹
黑龙江中医药大学研究生院, 黑龙江哈尔滨 150040
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郭思凡
郭思凡
黑龙江中医药大学研究生院, 黑龙江哈尔滨 150040
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杨强
杨强
黑龙江中医药大学研究生院, 黑龙江哈尔滨 150040
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邱时
邱时
海南医学院科学实验中心, 海南省热带心血管病研究重点实验室, 中医药与现代医学国际联合研究中心(海南医学院-欧洲自然科学院), 国际先进功能组学技术平台, 海南海口 571199
通讯作者.
Email: qiushihnyx@163.com
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张爱华
张爱华
海南医学院科学实验中心, 海南省热带心血管病研究重点实验室, 中医药与现代医学国际联合研究中心(海南医学院-欧洲自然科学院), 国际先进功能组学技术平台, 海南海口 571199
通讯作者.
Email: aihuatcm@163.com
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Study on efficacy and substance basis of traditional Chinese medicine based on metabolomics method

WANG Zhibo
WANG Zhibo
Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040 China
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CAI Ying
CAI Ying
Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040 China
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GUO Sifan
GUO Sifan
Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040 China
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YANG Qiang
YANG Qiang
Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040 China
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QIU Shi
QIU Shi
International Advanced Functional Omics Platform, International Joint Research Center on Traditional Chinese and Modern Medicine(Hainan Medical University and Europäische Akademie der Naturwissenschaften), Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Scientific Experiment Center, Hainan Medical University, Haikou 571199, China
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Email: qiushihnyx@163.com
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ZHANG Aihua
ZHANG Aihua
International Advanced Functional Omics Platform, International Joint Research Center on Traditional Chinese and Modern Medicine(Hainan Medical University and Europäische Akademie der Naturwissenschaften), Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Scientific Experiment Center, Hainan Medical University, Haikou 571199, China
Contact Author.
Email: aihuatcm@163.com
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发布日期：2023-09-07

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[关键词]

代谢组学 ; 生物标志物 ; 中药药效评价 ; 药效物质 ; 作用机制 ; 质量标志物

[摘要]

中医药在新型冠状病毒疫情防控方面起到重要作用，让世界对中医药有了新的认识。但是，由于中医药的作用机制、药效物质、分子靶标等不明确，限制其广泛应用。代谢组学的出现为这一系列问题的解决提供切实可行的技术方法。通过对近2年有关文献的查阅，阐述代谢组学在证候或疾病的表征以及中药的药效评价、药效物质、作用机制、质量标志物等方面的研究进展，以期为代谢组学在中医药作用机制、药效物质等方面的深入研究提供参考。

[Key word]

metabolomics ; biomarkers ; efficacy evaluation of traditional Chinese medicine ; effective substances ; mechanism of action ; Q-markers

[Abstract]

Traditional Chinese medicine (TCM) plays an important role in the prevention and control of COVID-19, which gives the world a new understanding of TCM. Due to the unclear mechanism of action, effective substances and molecular targets, its wide application is limited. The emergence of metabolomics provides a feasible technical method for solving this series of problems. Through the review of relevant literature in the past two years, this paper expounds the research progress of metabolomics in the characterization of syndromes / diseases, the evaluation of efficacy, effective substances, mechanism of action, quality markers and other aspects of TCM, in order to provide reference for the research of metabolomics in TCM.

[中图分类号]

R285.5

[基金项目]

国家自然科学基金自助项目（81973745，82104733）

引用本文 / Get Citation

王志博,蔡莹,郭思凡,杨强,邱时,张爱华.基于代谢组学方法的中药药效及物质基础的研究进展[J].药物评价研究,2023,46(9):2024-2029

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收稿日期: 2023-04-06

在线发布日期: 2023-09-07

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