目的 探讨济生乌梅片对预防胃及十二指肠息肉内镜下切除术后复发的疗效。方法 按照纳入标准以2020年1月— 2022年3月在重庆市中医院消化科门诊或住院部就诊，并在本院行胃镜检查及手术治疗的胃和（或）十二指肠息肉患者共83例为研究对象，根据治疗方案不同分为对照组（n＝42）和试验组（n＝41）。对照组采取胃镜下息肉切除术［息肉切除方式包括息肉冷切除、息肉的氩气刀治疗术及黏膜切除术（EMR术）］治疗，试验组在胃镜下息肉切除后，继续给予济生乌梅片治疗，每次3片，每日3次，连续服用3个月。比较两组患者术后1年胃及十二指肠息肉的复发率、临床症状缓解情况及肿瘤标志物的变化情况。结果 两组治疗1年后患者临床症状（腹胀、嗳气及腹痛）均有改善（P<0.05）。肿瘤标志物CA72-4水平在两组中治疗后均有降低（P<0.05）。试验组术后息肉复发率（26.83%）明显低于对照组（64.29%，P< 0.05）。结论 内镜下息肉切除术联合术后济生乌梅片治疗可改善患者的主要临床症状，降低CA72-4的表达。术后联用济生乌梅片对预防胃及十二指肠息肉术后复发疗效佳。

Objective To explore the efficacy of Jisheng Wumei Tablets in preventing recurrence after endoscopic resection of gastric and duodenal polyps. Method According to the inclusion criteria, a total of 83 patients with gastric and/or duodenal polyps who visited the gastroenterology outpatient or inpatient department of Chongqing Traditional Chinese Medicine Hospital from January 2020 to March 2022 and underwent gastroscopy and surgical treatment in the hospital were studied. They were divided into a control group (n= 42) and an experimental group (n= 41) according to different treatment plans. The control group received polypectomy under gastroscopy [polypectomy methods include cold polypectomy, argon knife treatment of polyps, and mucosal resection (EMR)], while the experimental group continued to receive Jisheng Wumei Tablets after polypectomy under gastroscopy, taking three tablets each time, three times a day, for a continuous period of three months. Compare the recurrence rate, clinical symptom relief, and changes in tumor markers of gastric and duodenal polyps between two groups of patients one year after surgery. Results After one year of treatment, the clinical symptoms (bloating, belching, and abdominal pain) of both groups of patients improved (P<0.05). The level of tumor marker CA72-4 decreased in both groups after treatment (P< 0.05). The recurrence rate of postoperative polyps in the experimental group (26.83%) was significantly lower than that in the control group (64.29%, P< 0.05). Conclusion Endoscopic polypectomy combined with postoperative Jisheng Wumei Tablets can improve the main clinical symptoms of patients and reduce the expression of CA72-4. The combined use of Jisheng Wumei Tablets after surgery has a better therapeutic effect on preventing postoperative recurrence of gastric and duodenal polyps.

R975

重庆市卫生计生委中医药科技项目（ZY201802076）