中药注射剂（TCMIs）起效快、疗效确切、临床应用广泛，但其类过敏反应（ARs）等不良事件已成为中药安全性研究的热点和难点。近年来，为加快推进TCMIs安全性再评价，深入了解TCMIs相关ARs的症状特点、致敏成分、作用机制等，研究者采用体内实验（ARs症状观察法、伊文思蓝蓝染法、组织病理学检查法）、体外实验（甲基四氮唑与细胞计数试剂盒-8法、染色法、膜黏连蛋白V结合法等）方法对ARs进行了评估，可为建立可靠的评价方法提供依据，为临床TCMIs相关ARs的早期识别、风险防控提供新思路。

Traditional Chinese medicine injections (TCMIs) have been widely used in clinical because of their rapid onset of action and precise efficacy, while their anaphylactoid reactions (ARs) and other adverse events have become a hot spot and a difficult area for safety research on traditional Chinese medicine. In recent years, in order to accelerate the safety re-evaluation of TCMIs and to gain a deeper understanding of the symptom characteristics, allergenic components and mechanisms of TCMIs-related ARs. The reseachers evaluated ARs using in vivo experiments (ARs symptom observation method, Evans blue staining method, histopathological examination method) and in vitro experiments (methyl tetrazolium and cell counting kit-8 method, staining method, membrane adhesion protein V binding method). It can provide a basis for establishing scientific and reliable evaluation methods, and provide new ideas for early identification, risk prevention and control of of clinical TCMIs-related ARs.

R969.3；R285.5

国家自然科学基金资助项目（82174069）；湖南省教育厅科学研究项目（21B0375）；湖南省卫健委科研计划课题（C202313057956）