目的 系统评价升降散联合西医常规治疗脓毒症的有效性和安全性。方法 计算机检索中国学术期刊全文数据库（CNKI）、万方数据知识服务平台（Wanfang Data）、维普中文期刊全文数据库（VIP）、PubMed、Cochrane Library、Embase、Web of Science数据库中升降散治疗脓毒症的随机对照试验（RCT），借助RevMan 5.4软件进行Meta分析。结果 共纳入13项RCTs，共720例患者。Meta分析结果表明，试验组（加用升降散）与对照组（西医常规治疗）比较，可提高中医证候疗效［OR＝7.04，95% CI（2.85，17.35），P<0.000 01］，降低中医证候积分［MD＝-1.50，95% CI（-1.97，-1.04），P<0.000 01］、急性生理与慢性健康评分［MD＝-2.56，95% CI（-3.64，-1.49），P<0.000 01］、白细胞计数［MD＝-1.57，95% CI（-2.14，-1.00），P<0.000 01］、C反应蛋白水平［MD＝-10.01，95% CI（-15.51，-4.52），P＝0.000 4］，肿瘤坏死因子-α水平［MD＝-7.41，95% CI（-13.22，-1.61），P＝0.01］、白细胞介素-6水平［MD＝-7.71，95% CI（-13.92，-1.50） ，P＝0.01］，表明升降散在改善症状和降低炎症方面有显著优势；在安全性方面，两组比较无统计学差异。结论 升降散治疗脓毒症的疗效显著，可降低炎症反应，且安全性较高，适用于临床联合用药。

Objective To systematically evaluate the efficacy and safety of Shengjiang Powder combined with conventional western medicine in the treatment of sepsis. Methods Databases such as CNKI, Wanfang Data, VIP, PubMed, Cochrane Library, Embase, and Web of Science were searched by computer for the randomized controlled trial (RCT) of Shengjiang Powder in the treatment of sepsis, the data was analyzed with RevMan 5.4 software. Results A total of 13 RCTs were included, including 720 patients. Metaanalysis results showed that adding to Shengjiang Powder conventional western medicine treatment improved curative effect of traditional Chinese medicine (TCM) syndrome[OR=7.04, 95%CI (2.85, 17.35), P < 0.000 01], reduced the TCM syndrome score[MD=-1.50, 95%CI (-1.97,-1.04), P < 0.000 01], acute physiology and chronic health score[MD=-2.56, 95%CI (-3.64,-1.49), P < 0.000 01], WBC count[MD=-1.57, 95%CI (-2.14,-1.00), P < 0.000 01], C-reactive protein level[MD=-10.01, 95%CI (-15.51,-4.52), P＝0.000 4], tumor necrosis factor-α level[MD=-7.41, 95%CI (-13.22,-1.61), P＝0.01], interleukin-6 level[MD=-7.71, 95%CI (-13.92,-1.50), P＝0.01], indicators are statistically significant, indicating that Shengjiang Powder has significant advantages in improving symptoms and reducing inflammation. There was no statistical difference in safety between the two groups. Conclusion Shengjiang Powder is effective in the treatment of sepsis, which can reduce the inflammatory reaction of sepsis and has high safety, so it is suitable for clinical combined use.

R287.5

国家重点研发计划项目（2018YFC1707503）；天津市中医药重点领域科研项目（2021010）；天津市卫生健康委、天津市中医药管理局中医中西医结合科研课题（2021098）