中药注射剂因药物相互作用引起的不良反应问题日益凸显，而细胞色素P450（CYP450）酶是影响药物体内处置过程的重要因素，其表达和功能的改变常常引起药动学的变化，是代谢性药物相互作用的主要靶点。因此，开展中药注射剂与化学药的药物相互作用研究十分必要，就CYP450酶介导的中药注射剂与化学药相互作用的研究现状以及常见的中药注射剂对CYP450酶影响的研究进行综述，为中药注射剂的临床应用和相互作用研究提供参考。

The adverse reactions caused by drug interactions in traditional Chinese medicine injections have become increasingly prominent. However, the herb-drug interaction caused by its combination with western medicine has attracted more and more attention. Cytochrome P450 (CYP450) enzyme is an important factor affecting the drug disposal process in vivo, and the change of its expression and function often leads to the change of pharmacokinetics, which is the main target of metabolic drug interaction. Therefore, it is necessary to study the herb-drug interaction of traditional Chinese medicine injections with chemical drugs. The current research status of traditional Chinese medicine injections mediated by CYP450 enzyme on chemotherapeutic drug interaction and the studies on the influence of common traditional Chinese medicine injections on CYP450 enzyme were reviewed, in order to provide reference for the clinical application and interaction research of traditional Chinese medicine injections.

R285.5；R965.3

天津市教委科研计划项目（2021ZD030）