目的 系统性评价复方丹参滴丸治疗糖尿病合并无症状性心肌缺血的疗效及安全性，为该药实践和决策于临床提供循证依据。方法 计算机检索中国学术期刊全文数据库（CNKI）、万方数据库（Wanfang Data）、中国生物医学文献数据库（CBM）、维普中文科技期刊数据库（VIP）、PubMed、Embase、Web of Science及Cochrane Library数据库，检索时限均为建库至2022年11月，收集复方丹参滴丸联用常规化学药（试验组）对比常规化学药（对照组）治疗糖尿病合并无症状性心肌缺血的随机对照试验（RCT），采用 RevMan 5.3 软件进行 Meta 分析。结果 共纳入 18 项 RCTs，共计 1 530 例患者。Meta分析结果显示，复方丹参滴丸治疗糖尿病合并无症状性心肌缺血的总有效率［RR=1.18，95%Cl（1.13，1.22）］试验组明显高于对照组，差异有统计学意义（P＜0.05）；试验组改善糖尿病合并无症状性心肌缺血血浆脂联素（APN）水平［MD=2.65，95%Cl（2.22，3.08）］、同型半胱氨酸（HCY）水平［MD=-8.31，95%Cl（-8.84，-7.79）］、红细胞（RBC）水平［MD=0.13，95%CI（0.11，0.15）］、白细胞（WBC）水平［MD=0.08，95%CI（0.01，0.16）］明显优于对照组，差异均有统计学意义（P＜0.05）。结论 复方丹参滴丸联合常规药物治疗糖尿病合并无症状性心肌缺血的临床疗效较好，可改善HCY水平、APN水平、RBC水平及WBC水平，且具有良好的安全性。

Objective To systematically evaluate the efficacy and security of Compound Danshen Dropping Pills in the treatment of diabetes mellitus complicated myocardial ischemia, so as to provide evidence-based basis for clinical practice and decision-making.Methods CNKI, Wanfang Data, CBM, VIP, PubMed, Embase, Web of Science, and Cochrane Library database were searched by computer to collect the randomized controlled trial (RCT) of combination of Compound Danshen Dropping Pills (trial group) and conventional western medicine (control group) in the treatment of diabetes mellitus complicated with asymptomatic myocardial ischemia. The database was established from November 2022. Meta-analysis was performed by RevMan 5.3 software.Results A total of 18 RCTs with 1 530 patients were included. The results of Meta-analysis showed that the total effective rate of Compound Danshen Dripping Pills in the treatment of diabetes mellitus complicated with asymptomatic myocardial ischemia [RR = 1.18, 95%CI (1.13, 1.22)] was significantly higher than that in the control group. The levels of plasma adiponectin (APN) [MD = 2.65, 95%CI (2.22, 3.08)], homocysteine (HCY) [MD = -8.31, 95%Cl (-8.84, -7.79)], red blood cell (RBC) [MD = 0.13, 95%CI (0.11, 0.15)] and white blood cell (WBC) [MD = 0.08, 95%CI (0.01, 0.16)] in diabetes mellitus complicated with asymptomatic myocardial ischemia group were improvedandwas significantly better than that in the control group, and the difference was statistically significant (P < 0.05).Conclusion Compound Danshen dripping pills combined with conventional drugs is effective in the treatment of diabetes mellitus complicated with asymptomatic myocardial ischemia and can improve the levels of HCY, APN, RBC and WBC, and has good security.

R286.2；R969.3

陕西省科技厅项目（2022SF-270）