目的 探讨连花清瘟颗粒联合磷酸奥司他韦治疗流行性感冒 （风热犯卫证） 的疗效及对患者免疫功能的影响。方法 前瞻性选取 2019年 1月—2020年 5月南通市中医院收治的 140例流行性感冒 （风热犯卫证） 患者，采用随机对照非盲法将其分为对照组与试验组，每组各70例。两组患者予以对症治疗，对照组在对症基础上采用磷酸奥司他韦胶囊治疗，每次75 mg，每天2次，分别于早晚餐后30 min口服。试验组在对照组基础上加用连花清瘟颗粒治疗，每次1袋，每天3次，餐后30 min口服。两组患者均连续治疗5 d。评估两组临床疗效及不良反应。比较两组治疗前后中医证候积分、γ-干扰素（IFN-γ）、白细胞介素-6（IL-6）以及T淋巴细胞亚型水平。结果 试验组总有效率较对照组显著升高（P＜0.05）。两组患者治疗后中医证候积分及IFN-γ、IL-6、CD8⁺水平均较同组治疗前显著降低（P＜0.05），试验组患者治疗后中医证候积分及 IFN-γ、IL-6、CD8⁺水平均较对照组显著降低（P＜0.05）。两组患者治疗后 CD3⁺、CD4⁺及 CD4⁺/CD8⁺水平均较同组治疗前显著升高（P＜0.05），试验组患者治疗后 CD3⁺、CD4⁺及 CD4⁺/CD8⁺水平均较对照组显著升高（P＜0.05）。两组均未发生不良反应。结论 连花清瘟颗粒联合磷酸奥司他韦胶囊治疗流行性感冒（风热犯卫证）的疗效及安全性较高，其不仅能减轻患者中医临床症状，同时还能调节患者免疫功能，促进患者早日康复。

Objective To explore the therapeutic effect of Lianhua Qingwen Granule combined with oseltamivir on influenza (wind heat offending wei syndrome) and its influence on immune function.Methods A total of 140 cases of influenza patients with influenza (wind heat offending wei syndrome) in Nantong Traditional Chinese Medicine Hospital from January 2019 to May 2020 were divided into experimental group and control group by prospective randomized controlled unblinded method, with 70 cases in each group. Patients in two groups were treated symptomatically. On this basis, patients in the control group were treated with Oseltamivir Phosphate Capsule, 75 mg each time, twice a day, taken orally 30 minutes after breakfast and dinner. Patients in the experimental group were treated with Lianhua Qingwen Granules on the basis of the control group, one bag per time, three times a day, and orally taken 30 minutes after meals. Both groups of patients were treated continuously for five days. The clinical efficacy and the adverse reactions of the two groups were evaluated. The scores of the TCM symptom, γ-interferon (IFN-γ), interleukin-6(IL- 6) and T-lymphocyte subtypes before and after treatment were compared between the two groups.Results The total effective rate of patients in the experimental group was significantly higher than that in the control group (P < 0.05). TCM symptom score and IFN-γ, IL-6 and CD8⁺of two groups of patients after treatment were lower than those before treatment (P < 0.05), and TCM symptom score and IFN- γ, IL-6 and CD8⁺ of patients in the experimental group after treatment were lower than those in the control group (P < 0.05). After treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in both groups were higher than those before treatment (P < 0.05),and those in the experimental group were higher than those in the control group (P < 0.05). There was no adverse reaction occurred in both groups.Conclusion Lianhua Qingwen Granule combined with oseltamivir has high efficacy and safety in the treatment of influenza (wind heat offending wei syndrome). It can not only alleviate the symptoms of patients in traditional Chinese medicine, but also regulate the immune function of patients and promote their early recovery.

R974

南通市市级科技计划项目（MSZ20107）