脱氧胆酸是主要在盲肠和近端结肠由微生物作用生成的次级胆汁酸，具有一定的抗菌性和毒性。作为一种肿瘤刺激因子，脱氧胆酸可以起到诱导细胞凋亡、促进癌细胞增殖的作用，参与了胃部疾病、肠道疾病、食管疾病等众多疾病的发生与发展。就脱氧胆酸作为潜在作用靶点参与各种疾病的发病机制进行综述，以期为这些疾病的发病机制和治疗药物的研发提供思路。

Deoxycholic acid, a secondary bile acid produced mainly by microbial action in the cecum and proximal colon, which has certain antimicrobial properties and toxicity. As a tumor stimulating factor, deoxycholic acid can induce apoptosis and promote cancer cell proliferation, which was involved into the development of many diseases such as gastric diseases, intestinal diseases and esophageal diseases. Therefore, its review as a potential target in the pathogenesis of various diseases will provide ideas for the pathogenesis of diseases and drug research.

国家自然科学基金面上项目（82073988）