注射用益气复脉（冻干）临床用于冠心病劳累型心绞痛属气阴两虚证，以及冠心病导致的心功能不全等心血管系统疾病，对改善气阴两虚型的心力衰竭的心功能、调节血压疗效显著。综述近10年来注射用益气复脉（冻干）改善心功能、增强心肌收缩力、调节心肌能量代谢及调整血压的药理作用及机制［其作用机制包括抑制核转录因子-κB、丝裂原活化蛋白激酶（MAPK）降低心肌损伤、提高T-ATPase、Ca²⁺，Mg²⁺-ATPase和Na⁺，K⁺-ATPase酶活力改善心肌能量代谢，降低肾上腺素β受体激动药物异丙肾上腺素及相关血管内皮因子血管紧张素II（AngII）影响］，以期为后续的深入研究提供参考，为临床合理用药提供数据支持。

Yiqi Fumai Lyophilized Injection (YQFM) is clinically used in coronary heart disease fatigue angina pectoris which is a syndrome of Qi and Yin deficiency, and cardiovascular diseases such as cardiac dysfunction caused by coronary heart disease. It can improve the heart function of heart failure with Qi and Yin deficiency and regulate the blood pressure significantly. It was reviewed the main pharmacological effects of YQFM in recent years to improve cardiac function, regulate myocardial energy metabolism and adjust blood pressure and related mechanisms of action include enhanced the cardiac function by inhibiting the phosphorylation of NF-κB and mitogen-activated protein kinase (MAPK) signaling pathway; enhanced the activity of T-ATPase, Ca²⁺, Mg²⁺-ATPase and Na⁺, K⁺-ATPase to regulate myocardial energy metabolism. To reduce the effects of epinephrine β -agonist isoproterenol and the related vascular endothelial factor angiotensin II (AngII), in order to provide reference for further research and improvement of subsequent products, and provide data support for clinical medicatio.

R285.5;R286.2