威灵仙是我国常用的、多基原大宗中药材，具有抗炎镇痛、保护软骨、保肝、抗癌、抗菌抑菌、降糖等多种作用。其主要通过抑制炎性因子、抑制信号通路等发挥抗炎镇痛作用，通过调节相关因子、相关通路表达而抑制细胞凋亡等发挥保护软骨的作用，通过调节肝脏免疫、降低内毒素水平等发挥保肝作用，通过调节相关基因表达发挥抗癌作用，通过破坏细胞膜发挥抗菌作用，通过调控信号通路、平衡胰岛细胞数量发挥降糖作用。对近年来威灵仙的药理作用及作用机制进行梳理总结，以期为其进一步开发利用提供参考。

Clematidis Radix et Rhizoma is a commonly used, multi-based, bulk Chinese medicinal material in my country. Studies have shown that it has anti-inflammatory and analgesic, cartilage protection, liver protection, anticancer, antibacterial, antibacterial, hypoglycemic and other effects. After reviewing the literature, it was found that it mainly exerts anti-inflammatory and analgesic effects by inhibiting inflammatory factors and signaling pathways, and protects cartilage by regulating the expression of related factors and related pathways and inhibiting cell apoptosis. Endotoxin levels play a role in liver protection, anti-cancer effects by regulating the expression of related genes, antibacterial effects by destroying cell membranes, and hypoglycemic effects by regulating signaling pathways and balancing the number of islet cells. This article summarizes the pharmacological effects and mechanism of Clematidis Radix et Rhizoma in recent years, in order to provide a reference for the further development and utilization of Clematidis Radix et Rhizoma.

R285.5

山东省新旧动能转换重大产业攻关项目（鲁动能办[2021]23号）；山东省重点研发计划（重大科技创新工程）项目（2020CXGC010505，2021CXGC010508）