[关键词]
[摘要]
近年来，神经炎症在缺血性脑卒中中的作用引起广泛关注，小胶质细胞、星形胶质细胞及众多炎性因子参与了炎症反应，并涉及到多种炎症反应的信号通路。根据缺血性脑卒中神经炎症反机制可采取具有抗炎作用的药物治疗，包括非甾体类抗炎药、抗生素类、天然植物源抗炎药、血清蛋白酶抑制剂、他汀类、棉籽油等多种抗炎药物。就缺血性脑卒中的神经炎症反应机制及相关的抗炎药物的研究进展进行综述，为进一步探索现有药物的抗炎机制及开发新型抗炎药物提供参考，并为缺血性脑卒中提供新的治疗方向。
[Key word]
[Abstract]
In recent years, the role of neuroinflammation in ischemic stroke has gained wide attention.Microglia, astrocyte, inflammatory factors and many signaling pathway are involved in the inflammatory response.According to the mechanism of ischemic stroke inflammatory reaction, anti-inflammatory drugs can be adopted for ischemic stroke medication, including nonsteroidal anti-inflammatory drug, antibiotics, natural plant-derived anti-inflammatory drugs, serum protease inhibitors, statins, cottonseed oil, et al.In this review, the present progresses of neuroinflammation mechanisms of ischemic stroke and related antiinflammatory medications are summarized.This article provides reference for the further exploring the anti-inflammatory mechanism of existing drugs and developing new anti-inflammatory drugs, as well as providing new therapeutic directions for ischemic stroke.
[中图分类号]
R965;R971
[基金项目]
北京市医院管理中心“青苗”计划专项经费资助（QMS20200811、QMS20210806）；北京市医院管理中心“登峰”计划专项经费资助（DFL20190803）；首都科技领军人才项目资助（Z191100006119017）
