目的 基于国内外药品价值评估的研究现状、热点及发展趋势分析，提出我国药品价值评估研究的攻关方向与策略建议。方法 检索中国期刊全文数据库（CNKI）自建库至2021年9月和WebofScience核心数据库1993年至2021年10月发表的与药品价值评估相关文献，采用CiteSpace可视化软件从作者及机构、关键词及文献共被引等方面进行分析，构建药品价值评估知识图谱。结果 英文发文量2004年后猛增，发文量最高的作者为Yot Teerawattananon，而中文发文量在2015年后激增，发文量最高的作者为翟所迪；在作者与机构合作方面，国内各机构团队之间合作较紧密，国外主要集中于机构团队内部；在研究热点上，国内研究集中在中成药注射液、化疗药、单抗药等药品的有效性、安全性和经济性评价，而国外机构更加关注价值评估方法学的研究与评估变量的选择。结论 国内药品价值评估研究基本上处于跟随式研究，评估的规范性、透明性均需加强。未来应从药品价值评估工作规范性的加强，评估方法体系以及中成药特有的价值评估框架的构建等方面着力推进我国药品价值评估工作。

Objective To put forward the research direction and suggestions of Chinese drug value assessment in the future based on the analysis of the research status, hot spots and development trend of the drug value assessment in China and abroad.Methods The literatures related to value assessment published in CNKI from the establishment of the database to September, 2021 and Web of Science core database from 1993 to Octorber, 2021 were retrieved, and the Cite Space visualization software was used to construct the knowledge map of drug value assessment based on the analysis with the authors and institutions, keywords and references cocitation.Results The number of articles published in English increased rapidly after 2004, and the author with the highest number of articles was Yot Teerawattananon.However, the number of articles published in Chinese increased rapidly only after 2015, and the the author with the highest number of articles was Suodi Zhai.In terms of cooperation between authors and institutions, the domestic research teams had closer cooperation than the abroad.While the cooperation in foreign countries was mainly concentrated within the institutional teams.As for the hot research topics, the domestic research focused on the efficacy, safety and economic evaluation of Chinese medicine injection, chemotherapy drugs, monoclonal antibodies and other drugs, while foreign institutions paid more attention to the research on the assessment methodology and the selection of evaluation variables.Conclusion The research on drug value assessment in China is basically follow-up research, and the standardization and transparency of evaluation need to be strengthened.In the future, the standardization of drug value assessment should be strengthened, the evaluation method system and the unique evaluation framework of Chinese patent medicine should be constructed to promote drug value evaluation research.

R9

国家食品药品监督管理总局政策研究课题（G20150I）