二至丸由女贞子、墨旱莲两味药材组成，具有补益肝肾、滋阴止血的功效，在妇科疾病、肾病、肝病等领域均有广泛的临床应用基础。现代药理研究发现二至丸在保肝补肾、改善骨质疏松、围绝经期综合征、免疫调节、抗衰老、改善神经系统疾病等方面具有广泛的药理活性，并对二至丸保护肝脏、抗骨质疏松、抗衰老的作用机制与潜在通路开展了研究。对二至丸的药理作用研究进展进行综述，为进一步利用现代药理学手段阐明二至丸治疗肝肾阴虚证的机制、挖掘中药经典方“多成分、多靶点、多通路”的作用特点以及指导二至丸临床应用提供参考。

Erzhi Pill, a traditional Chinese medicinal formulation consists of Ligustri Lucidi Fructus and Ecliptae Herba, is widely used in the treatment of gynecological diseases, kidney diseases and liver diseases for the effect of tonifying liver and kidney,as well as nourishing yin and hemostasis. Extensive pharmacological activities such as liver and kidney protection, anti-osteoporosis, perimenopausal syndrome treatment, immune regulation, anti-aging, and nervous system diseases improvement were revealed by modern pharmacological research. Additionally, the mechanisms and potential pathways of Erzhi Pill in protecting liver, antiosteoporosis and anti-aging were studied. In this paper, the research progress of pharmacological effects of Erzhi Pill were comprehensively summarized to lay a foundation for further clarification of the mechanism of Erzhi Pill on liver-kidney yin deficiency syndrome by modern pharmacology, exploration of the characteristics of multi-component, multi-target and multipathway of traditional Chinese medicine, and clinical application of Erzhi Pill.

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