[关键词]
[摘要]
耐甲氧西林金黄色葡萄球菌(MRSA)是常见病原菌之一,并且其多重耐药菌株对人类健康造成了较大威胁。靶向毒力因子的MRSA抗毒力抑制剂可以在解决细菌感染问题的同时有效避免多重耐药的产生与发展,具有较大应用潜力。目前已知MRSA抗毒力抑制剂包括靶向ClpP蛋白酶的泽兰黄酮、槲皮苷,靶向转肽酶A的异牡荆苷,靶向转肽酶B的根皮素,靶向α-溶血素的胡椒碱、厚朴总酚,靶向生物膜的黄绵马酸BB及绿原酸代谢产物等。就上述MRSA抗毒力抑制剂的药理作用进行综述,旨在为MRSA抗毒力抑制剂的进一步研发提供参考。
[Key word]
[Abstract]
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the common pathogenic bacteria and the multiple drugresistant MRSA strains have threatened people's health. Anti-virulence inhibitors which inhibit MRSA virulence by targeting important virulence factors can effectively avoid the generation and development of multiple drug resistance while solving the problem of bacterial infection. Therefore, the study in anti-virulence inhibitors has great potential. At present, Anti-virulence inhibitors include nepetin and quercetin targeting ClpP, isovitexin targeting sortase A, phloretin targeting sortase B, piperine and total magnolol targeting α-hemolysin, flavaspidic acid BB and chlorogenic acid metabolities targeting biofilm, etc.In this paper, the recent research results of pharmacological actions and possible future research direction of the anti-virulence inhibitors above are summarized as follows, in order to provide reference for the further research and development of anti-virulence inhibitors.
[中图分类号]
R965
[基金项目]
吉林大学2021年大学生创新创业训练计划项目(S202110183547)