[关键词]
[摘要]
代谢性疾病发病缓慢且难以治愈,包括代谢相关脂肪性肝病、糖尿病、痛风等。莱菔硫烷是广泛存在于十字花科植物的异硫氰酸盐类化合物,具有抗炎、抗氧化、抗肿瘤等多种生物活性,而且可以通过减少脂肪积累、改善线粒体功能障碍、调节氧化平衡以及减少炎症因子表达对代谢性疾病发挥调节作用。对菜菔硫烷调节代谢性疾病的药理作用机制进行总结,以期为食源性植物化学成分用于代谢性疾病的预防和治疗提供新思路。
[Key word]
[Abstract]
Metabolic diseases are slow in onset and difficult to cure, including metabolic related fatty liver disease, diabetes and gout. Sulforaphane is a kind of isothiocyanate compound widely existing in Cruciferae plants, which has many biological activities such as anti-inflammatory, anti-oxidation and anti-tumor. Pharmacological studies have found that sulforaphane can play a regulatory role in metabolic diseases by reducing fat accumulation, improving mitochondrial dysfunction, regulating oxidative balance and reducing the expression of inflammatory factors. The pharmacological mechanism of sulforaphane in regulating metabolic diseases was summarized in order to provide new ideas for the prevention and treatment of food borne phytochemical components and metabolic diseases.
[中图分类号]
R285.5
[基金项目]
国家自然科学基金面上资助项目(81573135);黑龙江省教育厅科学技术研究项目(12541763);黑龙江中医药大学研究生创新科研项目(2022yjscx013)