和厚朴酚具有广泛的生物活性，如抗菌、抗病毒、抗肿瘤、抗炎、抗氧化和抗衰老作用，对消化、神经、心血管和呼吸系统等均有明显的药理活性。和厚朴酚是一种疏水性联苯酚类结构化合物，难溶于水，易溶于脂，在胃肠道吸收较差，但分布广泛，50%以上口服剂量的和厚朴酚经胃肠道排出体外，40%以上的和厚朴酚经代谢后排出体外。通过综述和厚朴酚药动学参数，体内过程，总结和厚朴酚的药动学研究进展，为合理用药提供参考。

Honokiol has widespread bioactivities, including anti-bacteria, anti-virus, anticancer, anti-inflammation, antioxidation and anti-aging, and has significant pharmacologic activities to alimentary system, nervous system, cardiovascular system and respiratory system. Honokiol is a hydrophobic compound of biphenol-type structure, and hardly dissolves in water, and freely dissolves in lipid. Honokiol is poorly absorbed in gastrointestinal tract, and widely distributed. 50% above oral dosage of honokiol is excluded from gastrointestinal tract, and 40% above dosage is excluded by metabolism. The pharmacokinectic parameters and process in body of honokiol are reviewed, and its research advances on pharmacokinetics is summarized, which provides a reference for rational utilization of honokiol.

R969.1