姜黄素（curcumin）是从姜黄中提取的多酚化合物，具有抗肿瘤、抗炎、抗菌等广泛的药理活性，但其溶解度低、生物利用度差、药动学差，限制了该药的临床应用。近年来，基于纳米技术的药物递送系统（主要包括纳米颗粒、脂质体、胶束、聚合物、纳米凝胶等）有效改善了姜黄素的生物利用度和溶解性，提高了体内药物活性。就姜黄素纳米制剂在消化系统肿瘤（胃癌、肝癌、结直肠癌、胰腺癌和食管癌）中的应用进行综述，旨在为姜黄素纳米制剂的进一步研究与利用提供参考。

Curcumin, a polyphenol compound extracted from Curcuma longa L., has a wide range of pharmacological properties such as anti-tumor, anti-inflammatory and antibacterial. However, its low solubility, poor bioavailability and poor pharmacokinetics which limit its therapeutic application. In recent years, the drug delivery system based on nanotechnology has effectively improved the bioavailability and solubility of curcumin, and improved the activity of this natural drug, mainly including nanoparticles, liposomes, micelles, polymers, and nanogels. This article reviews the application of curcumin nanoparticles in digestive system tumors (gastric cancer, liver cancer, colorectal cancer, pancreatic cancer and esophageal cancer), aiming to provide reference for further research and utilization of curcumin.