地骨皮甲素是结构独特的精胺类生物碱，为地骨皮的主要活性成分，具有抗氧化、抗炎、神经保护、抗肿瘤、降血糖、降血压、调血脂、抗虫、抗帕金森症等药理作用。现有文献对地骨皮甲素在神经保护、抗氧化、抗炎方面的研究比较完善；但存在缺乏抗菌、抗病毒的研究，降血压方面缺乏具体机制研究，神经退行性疾病研究不全面等不足。对近年来国内外地骨皮甲素的药理作用进行了综述，以期为后续研究和进一步药用开发提供参考。

Kukoamine A is a phenolic amide alkaloid in the active ingredients of Cortex Lycii Radicis, which has a unique chemical structure, and it has pharmacological effects such as antioxidant, anti-inflammatory, neuroprotective, antitumor, hypoglycemic, antihypertensive, lipid-lowering, insect-resistant, and Parkinson's disease-resistant, so it has great development value. It was found that the research on neuroprotection, antioxidation and anti-inflammation of kukoamine A is relatively complete; However, there are some deficiencies such as lack of research on antibacterial and antiviral, lack of specific mechanism research on blood pressure lowering, and incomplete research on neurodegenerative diseases.The researches on the pharmacological effects of kukoamine A at home and abroad in recent years were reviewed in order to provide reference for subsequent research and further pharmaceutical development.

R285.5

“十三五”南京市卫生青年人才培养第三层次资助项目(QRX17132)