多数生物体内存在固有的生物节律，它调节机体生命活动过程以适应外界环境的变化。昼夜节律由中央生物钟及外周生物钟共同协调控制。动脉粥样硬化性心血管疾病（ACVD）目前仍是世界范围内的第一大致死性因素。研究表明，ACVD的发病特点与生物钟之间具有高度相关性。主要介绍生物钟调节脂质代谢及免疫炎症反应的生物学作用，及其对局部血管功能的影响，探讨以生物钟为潜在靶点的药物研究现状及其对临床精准用药的指导，以期将生物钟疗法广泛应用于ACVD的治疗中。

Most organisms have internal biological rhythm, which regulate biological processes in response to changes in the daily environment. Circadian rhythms are coordinated by central clock and peripheral clock. Atherosclerosis cardiovascular disease (ACVD) is the main cause of death all over the world. Recent studies have shown that there is a strong correlation between the circadian clock and ACVD. In this review, we briefly summarize the key roles of circadian clock in ACVD, including regulation of lipid metabolism, inflammatory immunoreactions, vascular functions. And we also discuss the status quo of drug research based on circadian clock and its guidance on clinical precision medication, in order to apply the chronotherapy in the treatment of ACVD widely.

R972

山东省高等学校科技计划项目(J18KB117)