[关键词]
[摘要]
青黛(Indigo Naturalis)是传统中药,临床上已经用于治疗银屑病、急性早幼粒细胞白血病和溃疡性结肠炎。溃疡性结肠炎是一种慢性非特异性的炎症性肠病,近年来发病率逐渐上升。青黛及其效成分靛蓝和靛玉红治疗溃疡性结肠炎时取得显著疗效,其药理作用机制涉及抗炎、促黏膜愈合、维护肠道免疫稳态和调节肠道菌群等多个方面。对近年来青黛及其有效成分靛蓝和靛玉红抗溃疡性结肠炎的药理作用及其机制进行总结,以期为临床合理用药及抗溃疡性结肠炎新药研发提供依据。
[Key word]
[Abstract]
Indigo Naturalis, a traditional Chinese medicine, has been extensively used in the treatment of psoriasis, acute promyelocytic leukemia and ulcerative colitis (UC). UC is a chronic, nonspecific inflammatory disease of intestine with gradually increasing incidence in recent years. Indigo Naturalis and its active ingredients, indigo and indirubin, have been applied to treat UC with significant curative effects. The mechanisms include anti-inflammation, mucosal healing, and intestinal immune homeostasis maintaining. This article summarizes the pharmacological actions and potential mechanisms of Indigo Naturalis, indigo and indirubin in the treatment of UC in recent years, which provides some reference for the safety of clinical medication and drug discovery.
[中图分类号]
R285.5
[基金项目]
国家自然科学基金面上资助项目(81873084,81573690);双一流高校资助项目(CPU2018GY06)