胃癌是一种严重威胁人类生命健康的恶性肿瘤。姜黄素（curcumin）提取自姜黄Curcuma longa根茎，在体内外药理实验中表现出良好的抗胃癌作用，且具有较高的安全性。姜黄素抗胃癌作用机制主要包括抑制胃癌细胞增殖、阻滞细胞周期、诱导细胞凋亡及自噬、调控相关信号通路及基因表达、抑制细胞侵袭及迁移、诱导活性氧产生、抑制肿瘤血管及淋巴管生成、化疗增敏及逆转化疗耐药、减少胃酸分泌等。就姜黄素抗胃癌药理作用机制进行综述，为其进一步研究及抗胃癌新药研发提供参考。

Gastric cancer is a malignant tumor which threatens the human life and health seriously. Curcumin, a natural extract from the rhizome of turmeric (Curcuma longa), has shown potent anti-gastric cancer effects in many experiments both in vivo and in vitro, and has high security. The anti-gastric cancer mechanism of curcumin mainly includes inhibition of gastric cancer cell proliferation, arrest of cell cycle, induction of cell apoptosis and autophagy, regulation of related signaling pathways and gene expression, inhibi‐ tion of cell invasion and migration, induction of ROS generation, inhibiting tumor angiogenesis and lymphangiogenesis, chemo‐ therapy sensitization and reversal of chemotherapy resistance, and reducing gastric acid secretion. In this review, we summarize the mechanism of curcumin against gastric cancer to provide reference for the further study of curcumin against gastric cancer.

R285.5