左金方为元朝医家朱震亨创制的经典中药复方，始载于《丹溪心法》，仅由黄连、吴茱萸以6∶1比例组方，治疗肝火犯胃所致胁肋胀痛、吞酸呕吐等，如今不仅用于多种消化系统病症（如胃溃疡、胃炎、胃癌、幽门螺杆菌感染等），还在精神症状、非胃肠道肿瘤、高血压、糖尿病等非消化系统疾病的治疗中起到较好疗效，具有抗炎抗溃疡、抗肿瘤、抗菌等多种作用。就近5年来对左金方的化学成分与药理作用的研究进展进行归纳总结，同时对其未来可能的研究方向进行了展望，以期为其进一步综合开发利用奠定基础。

Zuojin Formula (ZJF), a classical herbal compound, is created by Zhu Zhenheng, a physician in Yuan Dynasty. First published in his classic "Dan Xi Xin Fa", it was only made from Rhizoma coptis and Evodia rutaecarpa respectively in a ratio of 6∶ 1, and the traditional dosage forms of it were water-bindered pill and decoction. Though it was originally used for the treatment of flank pain, gastric acid regurgitation and vomiting caused by liver-fire offending the stomach. Nowadays it can not only be used for a variety of digestive disorders, such as gastric ulcer, gastritis, gastric carcinoma and H. pylori infection, but also plays a pivotal role in the treatment of mental disorders, non-gastrointestinal tumor, hypertension, diabetes and other non-digestive diseases, showing multiple effects such as anti-inflammation, anti-ulcer, anti-tumor and anti-bacteria. This article comprehensively summarizes the research progress in respect of chemical compositions and pharmacological effects of ZJF in the past five years. At the same time prospects the possible research directions in the future, hoping to provide a reference for the further research.

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深圳市知识创新基础研究（JCYJ20170818094033689）；深圳市战略新兴产业发展专项资金（JCYJ20130326112248968）；深圳大学聚徒＋创研项目（2021年度）