目的 探究珍芪补血口服液联合多糖铁复合物对妊娠期缺铁性贫血的治疗效果。方法 回顾性选取2019年3月— 2020年6月凉山彝族自治州第二人民医院收治的112例妊娠期缺铁性贫血孕妇为研究对象，按照用药方案的不同将患者分为试验组和对照组，每组各56例。两组孕妇均遵医嘱口服维生素C及叶酸片。对照组在此基础上给予多糖铁复合物胶囊口服，0.3 mg/次，1次/d。试验组在对照组的基础上给予珍芪补血口服液，10 mL/次，2次/d。两组均治疗8周。对比两组孕妇临床疗效，比较两组患者治疗前后贫血相关指标，包括血红蛋白（Hb）、血清铁蛋白（SF）、红细胞平均体积（MCV）变化，比较两组患者治疗前后血清转铁蛋白受体（sTfR）、铁幼素（HJV）、膜铁转运蛋白1（FPN1）水平及免疫功能相关指标［辅助性T淋巴细胞（CD4⁺T）、成熟T细胞（CD3⁺T）、CD4⁺/抑制性T淋巴细胞（CD8⁺T）］，观察治疗后两组不良妊娠结局发生情况。结果 治疗前，两组各项指标比较差异均无统计学意义（P>0.05）。治疗后，试验组总有效率为98.21%，明显高于对照组的87.50%（P<0.05）。治疗后两组患者Hb、SF、MCV、HJV、CD4⁺T、CD3⁺T、CD4⁺/CD8⁺水平较治疗前均明显升高（P<0.05），且试验组明显高于对照组（P<0.05）。治疗后两组患者血清sTfR、FPN1水平较治疗前均明显降低（P<0.05），且试验组明显低于对照组（P<0.05）。两组产妇产后出血及胎儿窘迫、早产、低出生体质量儿等不良妊娠结局发生率差异无统计学意义（P>0.05）。结论 珍芪补血口服液联合多糖铁复合物治疗妊娠期缺铁性贫血疗效显著，可有效调节孕妇免疫功能，改善贫血症状，提高红细胞生产速度，且不会增加不良妊娠结局。

Objective To explore the therapeutic effect of Zhenqi Buxue Oral Liquid combined with polysaccharide iron complex on iron deficiency anemia during pregnancy. Methods Total 112 pregnant women with iron deficiency anemia during pregnancy treated in the Second People's Hospital of Liangshan Yi Autonomous Prefecture from March 2019 to June 2020 were retrospectively selected as the research object. According to the different medication schemes, the patients were divided into experimental group and control group, with 56 cases in each group. Both groups of pregnant women took vitamin C and folic acid tablets orally according to the doctor's advice. On this basis, patients in the control group were given polysaccharide iron complex capsule orally, 0.3 mg/time, once a day. On the basis of the control group, patients in the experimental group were given Zhenqi Buxue Oral Liquid, 10 mL/time, twice a day. Both groups were treated for eight weeks. The clinical efficacy of the two groups of pregnant women was compared, and the anemia related indexes of the two groups before and after treatment, including the changes of hemoglobin (Hb), serum ferritin (SF) and mean red blood cell volume (MCV). The levels of serum transferrin receptor (sTfR), ferritin (HJV), ferroportin-1 (FPN1) and immune function indexes [ auxiliary T lymphocytes (CD4⁺T), mature T cells (CD3⁺T), CD4⁺/inhibitory T lymphocytes (CD8⁺T)] were compared between the two groups before and after treatment. The adverse pregnancy outcomes of the two groups after treatment were observed. Results Before treatment, there was no significant difference in various indexes between two groups (P>0.05). After treatment, the total effective rate of the experimental group was 98.21%, which was significantly higher than 87.50% of the control group (P<0.05). After treatment, the levels of Hb, SF, MCV, HJV, CD4⁺T, CD3⁺T and CD4⁺/CD8⁺ in the two groups were significantly higher than those before treatment (P<0.05), and the levels in the experimental group were significantly higher than the control group (P<0.05). After treatment, the levels of serum sTfR and FPN1 in the two groups were significantly lower than those before treatment (P<0.05), and the levels in the experimental group were significantly lower than those in the control group (P<0.05). There was no significant difference in the incidence of postpartum hemorrhage, fetal distress, preterm birth and low birth weight infants between the two groups (P>0.05). Conclusion Zhenqi Buxue Oral Liquid combined with polysaccharide iron complex is effective in the treatment of iron deficiency anemia during pregnancy. It can effectively regulate the immune function of pregnant women, improve the symptoms of anemia, increase the rate of red blood cell production, and will not increase the adverse pregnancy outcome.

R984

凉山州学术和技术带头人培养资金资助项目（凉社办发<2018>147号）