目的 观察注射用益气复脉（冻干）对不稳定型心绞痛（气阴两虚证）患者低密度脂蛋白胆固醇（LDL-C）的影响及中医症候的疗效。方法 回顾性选取2020年6月—2021年6月淮北市中医院心内科住院的不稳定型心绞痛患者102例为研究对象，根据治疗方法将患者分为对照组（n=51）和观察组（n=51）。对照组患者给予阿托伐他汀钙片、阿司匹林肠溶片、硫酸氢氯吡格雷片、单硝酸异山梨酯缓释片等药物治疗，观察组患者在对照组基础上联合注射用益气复脉（冻干）5.2 g溶于0.9%氯化钠注射液200 mL中，静脉滴注，1次/d。两组治疗疗程均为2周。比较治疗前及治疗1周末、治疗2周末两组患者的心绞痛发作次数、中医症候积分、LDL-C等指标。结果 与治疗前比较，两组治疗1周末、治疗2周末患者心绞痛发作次数、中医症候积分均显著降低（P<0.05、0.01），与治疗1周末比较，观察组治疗2周末心绞痛发作次数、中医症候积分、LDL-C降低更明显（P<0.05）。与对照组同时间比较，观察组治疗1周末、治疗2周末的心绞痛发作次数、中医症候积分显著降低（P<0.05）；中医症候疗效观察组总有效率（86.3%）高于对照组（68.6%，P<0.05）；观察组的心绞痛改善情况总有效率（88.2%）优于对照组（70.6%，P<0.05）。结论 注射用益气复脉（冻干）能进一步改善不稳定型心绞痛（气阴两虚证）患者的LDL-C水平及中医症候积分，减少心绞痛发作，且安全、有效。

Objective To observe the effect of Yiqi Fumai Lyophilized Injection on low density lipoprotein cholesterol in patients with unstable angina pectoris (qi yin deficiency syndrome) and the curative effect on traditional Chinese medicine symptoms. Methods Total 102 patients with unstable angina pectoris hospitalized in the Department of Cardiology of Huaibei Hospital of traditional Chinese Medicine from June 2020 to June 2021 were selected retrospectively. According to the treatment methods, the patients were divided into control group (n=51) and observation group (n=51). The patients in the control group were treated with Atorvastatin Calcium Tablets, Aspirin Enteric Coated Tablets, Clopidogrel Bisulfate Tablets, Isosorbide Mononitrate for Injection, Isosorbide Mononitrate Sustained Release Tablets and other drugs. On the basis of the control group, the patients in the observation group were combined with 5.2 g of Yiqi Fumai Lyophilized Injection, dissolved in 200 mL of 0.9% sodium chloride injection, intravenous drip, once a day. The treatment course of both groups were two weeks. The frequency of angina pectoris attack, TCM symptom score, low density lipoprotein cholesterol (LDL-C) and other indexes were compared between two groups before treatment, at the end of the first week and at the end of the second weeks. Results Compared with before treatment, the number of angina pectoris attacks and TCM symptom score in two groups at the end of the first week and the second week of treatment were significantly lower (P<0.05, 0.01). Compared with the first week of treatment, the number of angina pectoris attacks, TCM symptom score and LDL-C in the observation group at the end of the second week of treatment were significantly lower (P<0.05). Compared with the control group at the same time, the number of angina pectoris attacks and TCM syndrome score in the observation group at the end of the first week and the second weeks after treatment were significantly reduced (P<0.05). The total effective rate of TCM syndrome effect observation group (86.3%) was higher than that in the control group (68.6%, P<0.05). The total effective rate of angina pectoris improvement observation group (88.2%) was better than that in the control group (70.6%, P<0.05). Conclusion Yiqi Fumai Lyophilized Injection can further improve the LDL-C level and TCM syndrome score of patients with unstable angina pectoris (qi yin deficiency syndrome), reduce the attack of angina pectoris, and is safe and effective.

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