目的 探讨注射用丹参多酚酸对急性缺血性脑卒中患者认知功能与运动功能的影响。方法 前瞻性选择2018年1月—2020年1月安阳市中医院收治的92例急性缺血性脑卒中患者为研究对象，随机分为对照组（n=46）与观察组（n=46）。对照组患者根据其具体的情况采取溶栓、抗凝、抗血小板聚集、改善微循环、减轻脑水肿、降低颅内压、调控血压、营养脑神经等常规治疗。观察组患者在对照组常规治疗基础上予以注射用丹参多酚酸0.13 g溶于0.9%氯化钠注射液250 mL中静脉滴注，1次/d，所有患者均治疗2周。观察比较两组患者的临床疗效，治疗前后的神经功能缺损、认知功能及运动功能评分变化情况。结果 观察组总有效率为91.30%，明显高于对照组的71.74%（P<0.05）。治疗前观察组与对照组神经功能缺损、认知功能及运动功能评分均无显著性差异（P>0.05），治疗后两组神经功能缺损评分及认知功能、运动功能评分均较治疗前明显改善，且观察组各评分改善程度明显优于对照组（P<0.05）。两组不良反应发生率无显著差异（P>0.05）。结论 注射用丹参多酚酸治疗急性缺血性脑卒中具有确切的临床疗效，且可有效改善患者的认知功能与运动功能，安全性高，值得临床上进一步推广。

Objective To investigate the effects of Salvianolic Acids for Injection on cognitive and motor function in patients with acute ischemic stroke. Methods Total 92 patients with acute ischemic stroke treated in Anyang Hospital of Traditional Chinese Medicine from January 2018 to January 2020 were prospectively selected as the research objects and randomly divided into control group (n=46) and observation group (n=46). The patients in the control group were treated with thrombolysis, anticoagulation, antiplatelet aggregation, improving microcirculation, reducing brain edema, reducing intracranial pressure, regulating blood pressure, nourishing brain nerves and so on. On the basis of routine treatment in the control group, the patients in the observation group were injected with Salvianolic Acids for Injection 0.13 g dissolved in 0.9% sodium chloride injection 250 mL intravenously, once a day. All patients were treated for two weeks. The clinical efficacy, neurological deficit, cognitive function and motor function scores of the two groups were observed and compared before and after treatment. Results The total effective rate in the observation group was 91.30%, which was significantly higher than 71.74% in the control group (P<0.05). Before treatment, there was no significant difference in the scores of neurological deficit, cognitive function and motor function between the observation group and the control group (P>0.05). After treatment, the scores of neurological deficit, cognitive function and motor function in the two groups were significantly improved compared with those before treatment, and the improvement degree of each score in the observation group was significantly better than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion Salvianolic Acids for Injection has definite clinical efficacy in treatment of acute ischemic stroke, and can effectively improve patients' cognitive function and motor function. It has high safety and is worthy of further promotion in clinic.

R971