[关键词]
[摘要]
氧化苦参碱可防治高糖、高脂引起的心血管并发症,脂肪肝并发症,糖尿病视网膜病变,糖尿病肾病以及肺、骨并发症。氧化苦参碱防治这些并发症的药理机制可能归因于:降血糖、调血脂及抗氧化作用,从源头上减少了氧化型低密度脂蛋白和糖基化终末产物的生成;抗氧化、抗炎和细胞保护作用可保护肝脏,促进肝糖原合成,在脂质转运、氧化和合成3个环节改善脂质代谢紊乱,产生降血糖、调血脂作用,也可保护受累的心血管系统、肾脏、肝脏、视网膜、肺和骨等其他器官,减轻胰岛素抵抗,提高胰岛素敏感性。因此氧化苦参碱有望开发为治疗代谢综合征的药物。
[Key word]
[Abstract]
Oxymatrine prevents and treats for cardiovascular complication, fatty liver complication, diabetic retinopathy, diabetic renopathy, and the complications of lung and bone induced by hyperglycystia and hyperliposis. The mechanisms to prevent and treat for the complications are:the effects on hypoglycemia, hypolipemia and antioxidation of oxymatrine decrease the products of AGEs and ox-LDL from source; the effects on antioxidation, anti-inflammation and cellular protection of oxymatrine protect liver, improve glycogen synthesis, and lipid metabolism disturbance in lipid transport, oxidation and synthesis, and product the effects of hypoglycemia and hypolipemia, protect suffering organs of cardiovascullar system, ren, liver, retina, lung and bone, alleviate insulin resistance, and increase insulin sensitivity. So oxymatrine is hopeful to become a drug of treating metabolic syndrome.
[中图分类号]
R285
[基金项目]