[关键词]
[摘要]
目的 评价参芪扶正注射液辅助化疗干预晚期胃癌患者的有效性及对患者免疫功能的影响。方法 检索中英文数据库,包括中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普生物医学数据库(VIP)、万方数据库、Cochrane Library、PubMed、Embase等,检索时间为建库至2021年6月,筛选参芪扶正注射液辅助治疗晚期胃癌的临床对照试验,采用RevMan 5.3软件对纳入的研究进行Meta分析。结果 共纳入8篇研究,662例患者。Meta分析结果显示:相较于对照组,参芪扶正注射液辅助化疗可以提高临床疗效[RR=1.36,95% CI=(1.22,1.51)];提高表面抗原分化簇3(CD3+)水平[SMD=1.25,95% CI=(1.04,1.46)]、表面抗原分化簇4(CD4+)水平[SMD=1.25,95% CI=(0.88,1.95)]、表面抗原分化簇8(CD8+)水平[SMD=-1.68,95% CI=(-1.92,-1.44)],CD4+/CD8+[SMD=1.10,95% CI=(0.86,1.34)],且差异均有统计学意义(P<0.01)。结论 参芪扶正注射液辅助化疗可以改善免疫功能,降低相关指标水平,综合提高晚期胃癌患者的近期疗效,但相关研究较少,化疗方案不统一,各研究纳入的患者数量相对较少,相关指标存在一定的异质性,对患者生存时间的评估仍需要更深入的临床研究。
[Key word]
[Abstract]
Objective To evaluate the efficacy of Shenqi Fuzheng Injection as adjuvant chemotherapy in patients with advanced gastric cancer and its effect on immune function. Methods Chinese and English databases were searched, including CNKI, CBM, VIP, Wanfang, Cochrane Library, PubMed, Embase, etc., from the establishment of the database to June 2021. Screening the clinical controlled trial of shenqi Fuzheng injection in the adjuvant treatment of advanced gastric cancer. Meta-analysis was performed on the included studies using RevMan 5.3 software. Results A total of 662 patients were included in 8 studies. Meta-analysis showed that compared with the control group, Shenqi Fuzheng Injection assisted chemotherapy could improve the clinical efficacy[RR=1.36, 95%CI=(1.22, 1.51)]; increased the level of CD3+[SMD=1.25, 95%CI=(1.04, 1.46)], CD4+[SMD=1.25, 95%CI=(0.88, 1.95)], CD8+[SMD=-1.68, 95%CI=(-1.92, -1.44)], CD4+/CD8+[SMD=1.10, 95%CI=(0.86, 1.34)], and the differences were statistically significant (P<0.01). Conclusion Shenqi Fuzheng Injection adjuvant chemotherapy can improve the immune function, lower levels of related indicators, comprehensive improve the recent curative effect of patients with advanced gastric cancer, but the related research is less, chemotherapy regimens are not unified, the research into the relatively small number of patients, the index has certain heterogeneity, survival time of patients of evaluation still needs further clinical research.
[中图分类号]
R286.5
[基金项目]
国家自然科学基金青年基金资助项目(81803951);国家自然科学基金面上资助项目(8197667)